1-Phenyl-4-(trimethylsilyl)butan-1-one

Base Information

• Chemical Name: 1-Phenyl-4-(trimethylsilyl)butan-1-one
• CAS No.: 17337-21-2
• Molecular Formula: C13H20OSi
• Molecular Weight: 220.387
• Hs Code.: 2931900090
• DSSTox Substance ID: DTXSID40434183
• Nikkaji Number: J303.555G
• Wikidata: Q82248523
• Mol file: 17337-21-2.mol

Synonyms:17337-21-2;1-phenyl-4-trimethylsilylbutan-1-one;1-Phenyl-4-(trimethylsilyl)-1-butanone;1-Phenyl-4-(trimethylsilyl)butan-1-one;SDK-31;DTXSID40434183;{(trimethylsilyl)ethyl}acetophenone

Chemical Property of 1-Phenyl-4-(trimethylsilyl)butan-1-one

Chemical Property:

• PSA: 17.07000
• LogP: 3.98770
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 220.128341792
• Heavy Atom Count: 15
• Complexity: 199

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)CCCC(=O)C1=CC=CC=C1

Technology Process of 1-Phenyl-4-(trimethylsilyl)butan-1-one

There total 10 articles about 1-Phenyl-4-(trimethylsilyl)butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzaldehyde (100-52-7) → γ-(trimethylsilyl)butyrophenone (17337-21-2)

Guidance literature:

With zinc dibromide; In tetrahydrofuran; at 25 ℃; for 6h;

DOI:10.1021/jo00116a007

Reference yield: 78.0%

cyclopropyltrimethylsilylmethanone (104823-92-9) + phenyllithium (591-51-5) → γ-(trimethylsilyl)butyrophenone (17337-21-2)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 0.666667h;

DOI:10.1016/j.tet.2004.10.099

Reference yield: 50.0%

4-iodobutyrophenone (65488-05-3) + C14H30O2SiZn → γ-(trimethylsilyl)butyrophenone (17337-21-2) + 8-oxo-8-phenyloctyl pivalate

Guidance literature:

With para-fluorostyrene; tetra-(n-butyl)ammonium iodide; bis(acetylacetonate)nickel(II); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at -20 ℃; for 6h;

DOI:10.1021/jo0105787

upstream raw materials:

γ-(trimethylsilyl)-n-butyronitrile

1,1,1,2,2,2-hexamethyldisilane

1-phenyl-1-cyclopropylmethanol

cyclopropyl phenyl ketone

Downstream raw materials:

acetophenone

phenacylacetophenone

ethenyltrimethylsilane