Ethyl 2-chloro-5-nitronicotinate

Base Information

Chemical Name:Ethyl 2-chloro-5-nitronicotinate
CAS No.:179689-21-5
Molecular Formula:C13H23NO5
Molecular Weight:230.60500
Hs Code.:
Mol file:179689-21-5.mol

Synonyms:methyl 2-(N-prop-2'-ynyl)aminobenzoate;MeCO (CH2)2Me;pentan-2-one;Methyl N-Propargylanthranilate;methyl N-tert-butyloxycarbonyl-4-piperidinyloxyacetate;n-propyl methyl ketone;methyl propyl ketone;methyl n-propyl ketone;Benzoic acid,2-(2-propynylamino)-,methyl ester (9CI);Benzoic acid,2-(2-propynylamino)-,methyl ester;

Suppliers and Price of Ethyl 2-chloro-5-nitronicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-(2-methoxy-2-oxoethoxy)piperidine-1-carboxylate 95+%
1g
$ 299.00

Chemenu
tert-butyl4-(2-methoxy-2-oxoethoxy)piperidine-1-carboxylate 95%
1g
$ 282.00

American Custom Chemicals Corporation
4-METHOXYCARBONYLMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00%
5MG
$ 505.29

Alichem
tert-Butyl4-(2-methoxy-2-oxoethoxy)piperidine-1-carboxylate
1g
$ 253.76

Total 4 raw suppliers

Chemical Property of Ethyl 2-chloro-5-nitronicotinate

Chemical Property:

PSA：85.01000
LogP:2.34310
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(2-methoxy-2-oxoethoxy)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Ethyl 2-chloro-5-nitronicotinate

There total 1 articles about Ethyl 2-chloro-5-nitronicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 96-32-2
bromoacetic acid methyl ester

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 179689-21-5
tert-butyl 4-(2-methoxy-2-oxoethoxy)piperidine-1-carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 74.0%

: 179689-21-5
tert-butyl 4-(2-methoxy-2-oxoethoxy)piperidine-1-carboxylate

: 163210-40-0
tert-butyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

: 179689-21-5
tert-butyl 4-(2-methoxy-2-oxoethoxy)piperidine-1-carboxylate

: tert-butyl 4-[2-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(ethylamino)-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-8-yl]ethoxy]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

2: triphenylphosphine; iodine; 1H-imidazole / dichloromethane / 2 h / 20 °C

3: potassium carbonate / acetonitrile / 70 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

5: triethylamine / tert-butyl alcohol / 2 h / 50 °C

With 1H-imidazole; lithium aluminium tetrahydride; iodine; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile; tert-butyl alcohol;