1-Piperidinecarboxylic acid, 4-[4-[[(7-cyano-2-naphthalenyl)methyl](methylsulfonyl)amino]phenoxy]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[4-[[(7-cyano-2-naphthalenyl)methyl](methylsulfonyl)amino]phenoxy]-, 1,1-dimethylethyl ester
CAS No.:179756-21-9
Molecular Formula:C29H33N3O5S
Molecular Weight:535.664
Hs Code.:
Mol file:179756-21-9.mol

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 4-[4-[[(7-cyano-2-naphthalenyl)methyl](methylsulfonyl)amino]phenoxy]-, 1,1-dimethylethyl ester

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Technology Process of 1-Piperidinecarboxylic acid, 4-[4-[[(7-cyano-2-naphthalenyl)methyl](methylsulfonyl)amino]phenoxy]-, 1,1-dimethylethyl ester

There total 14 articles about 1-Piperidinecarboxylic acid, 4-[4-[[(7-cyano-2-naphthalenyl)methyl](methylsulfonyl)amino]phenoxy]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 124-63-0
methanesulfonyl chloride

: 179755-93-2
7-({4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-anilino}methyl)naphthalene-2-carbonitrile

: 179756-21-9
N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]methanesulfonamide

Guidance literature:: With pyridine; at 3 ℃; for 15h;
DOI:10.1016/S0968-0896(01)00418-7

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 179756-21-9
N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran

2: H₂ / 10 percent Pd/C / methanol / 760 Torr

3: pyridine

4: Cs₂CO₃ / dimethylformamide

With pyridine; hydrogen; sodium hydride; caesium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00927-7

Reference yield:

: 138227-62-0
tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

: 179756-21-9
N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10 percent Pd/C / methanol / 760 Torr

2: pyridine

3: Cs₂CO₃ / dimethylformamide

With pyridine; hydrogen; caesium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00927-7