3-Acetyl-5-(hydroxydiphenylmethyl)-2,2-dimethyl-4-methoxyoxazolidin

Base Information

• Chemical Name: 3-Acetyl-5-(hydroxydiphenylmethyl)-2,2-dimethyl-4-methoxyoxazolidin
• CAS No.: 107557-46-0
• Molecular Formula: C₂₁H₂₅NO₄
• Molecular Weight: 355.434
• Mol file: 107557-46-0.mol

Synonyms:

Chemical Property of 3-Acetyl-5-(hydroxydiphenylmethyl)-2,2-dimethyl-4-methoxyoxazolidin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Acetyl-5-(hydroxydiphenylmethyl)-2,2-dimethyl-4-methoxyoxazolidin

There total 3 articles about 3-Acetyl-5-(hydroxydiphenylmethyl)-2,2-dimethyl-4-methoxyoxazolidin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethyloxazolidine (20515-62-2) → 3-Acetyl-5-(hydroxydiphenylmethyl)-2,2-dimethyl-4-methoxyoxazolidin (107557-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NEt₃ / 12 h / Ambient temperature

2: 1) C₆H₅-CO-COO-C₄H₉, CuI / 1) C₆H₆, 110 deg C, 40 h, 2) 150 deg C

3: 2) Lewatit-S₁₀₀ / 1) benzen, irradiation, 2) CH₃OH, 15 h, r.t.

With copper(l) iodide; Lewatit-S₁₀₀; n-butyl 2-oxo-2-phenylacetate; triethylamine;

Reference yield:

N-acetyl-2,2-dimethyloxazolidine (5050-58-8) → 3-Acetyl-5-(hydroxydiphenylmethyl)-2,2-dimethyl-4-methoxyoxazolidin (107557-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) C₆H₅-CO-COO-C₄H₉, CuI / 1) C₆H₆, 110 deg C, 40 h, 2) 150 deg C

2: 2) Lewatit-S₁₀₀ / 1) benzen, irradiation, 2) CH₃OH, 15 h, r.t.

With copper(l) iodide; Lewatit-S₁₀₀; n-butyl 2-oxo-2-phenylacetate;

Reference yield:

methanol (67-56-1) + benzophenone (119-61-9) + 3-Acetyl-2,3-dihydro-2,2-dimethyloxazol (107557-35-7) → 3-Acetyl-5-(hydroxydiphenylmethyl)-2,2-dimethyl-4-methoxyoxazolidin (107557-46-0)

Guidance literature:

With Lewatit-S₁₀₀; Yield given. Multistep reaction; 1) benzen, irradiation, 2) CH₃OH, 15 h, r.t.;

upstream raw materials:

methanol

benzophenone

3-Acetyl-2,3-dihydro-2,2-dimethyloxazol

2,2-dimethyloxazolidine

Refernces