Benzene, 1-fluoro-4-(1-propyn-1-yl)-

Base Information

• Chemical Name: Benzene, 1-fluoro-4-(1-propyn-1-yl)-
• CAS No.: 18826-59-0
• Molecular Formula: C9H7F
• Molecular Weight: 134.153
• Mol file: 18826-59-0.mol

Synonyms:1-FLUORO-4-(1-PROPYN-1-YL)-BENZENE;Phosphorsaeure-dihexadecylester;Natrium-Salz;BENZENE,1-FLUORO-4-(1-PROPYN-1-YL)-;

Chemical Property of Benzene, 1-fluoro-4-(1-propyn-1-yl)-

Chemical Property:

• PSA: 0.00000
• LogP: 2.19710

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1-fluoro-4-(1-propyn-1-yl)-

There total 12 articles about Benzene, 1-fluoro-4-(1-propyn-1-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-fluoro-1-iodobenzene (352-34-1) + prop-1-yne (74-99-7) → 1-(4-fluorophenyl)-prop-1-yne (18826-59-0)

Guidance literature:

With copper(I) oxide; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide; at 135 ℃; for 8h; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201901530

Reference yield: 88.0%

1-(4-fluorophenyl)propan-1-one (456-03-1) → 1-(4-fluorophenyl)-prop-1-yne (18826-59-0)

Guidance literature:

With Nonafluorobutanesulfonyl fluoride; tert-butylimino-tri(pyrrolidino)phosphorane; In N,N-dimethyl-formamide; at 20 ℃; for 19h;

DOI:10.1055/s-0028-1087919

Reference yield: 79.0%

calcium carbide (75-20-7) + N-(4-fluorobenzylidene)-4-methylbenzenesulfonamide (193675-43-3) → 1-(4-fluorophenyl)-prop-1-yne (18826-59-0)

Guidance literature:

With copper(l) iodide; potassium tert-butylate; water; In N,N-dimethyl-formamide; at 90 ℃; for 6h;

DOI:10.1055/s-0037-1610718

upstream raw materials:

1-(4-fluorophenyl)propan-1-one

1-ethynyl-4-fluorobenzene

methyl iodide

2-Butynoic acid

Downstream raw materials:

1-(p-Fluorphenyl)-2-methyl-cyclopropen-3-carbonsaeure

(E)-3-(4-fluorophenyl)-2-methylacrylic acid

1-fluoro-4-(prop-1-en-1-yl)benzene