Phosphonic acid, [(4-bromophenyl)hydroxymethyl]-, dimethyl ester

Base Information

• Chemical Name: Phosphonic acid, [(4-bromophenyl)hydroxymethyl]-, dimethyl ester
• CAS No.: 20406-39-7
• Molecular Formula: C9H12BrO4P
• Molecular Weight: 295.07
• Mol file: 20406-39-7.mol

Synonyms:

Chemical Property of Phosphonic acid, [(4-bromophenyl)hydroxymethyl]-, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphonic acid, [(4-bromophenyl)hydroxymethyl]-, dimethyl ester

There total 4 articles about Phosphonic acid, [(4-bromophenyl)hydroxymethyl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-bromo-benzaldehyde (1122-91-4) + Dimethyl phosphite (868-85-9) → dimethyl (hydroxy(4-bromophenyl)methyl)phosphonate (20406-39-7)

Guidance literature:

4-bromo-benzaldehyde; With phosphotungstic acid supported on silica-coated magnetic Fe₃O₄ nanoparticle; In neat (no solvent); at 20 ℃; for 0.25h; Green chemistry;

Dimethyl phosphite; In neat (no solvent); at 20 ℃; for 6h; Green chemistry;

DOI:10.1002/cplu.201402191

Reference yield: 88.0%

4-bromo-benzaldehyde (1122-91-4) + phosphorous acid trimethyl ester (121-45-9) → dimethyl (hydroxy(4-bromophenyl)methyl)phosphonate (20406-39-7)

Guidance literature:

In neat liquid; for 0.283333h; Sonication; Green chemistry;

DOI:10.1007/s11164-015-2420-8

Reference yield:

dimethyl 1-hydroxy-1-phenylmethylphosphonate (6329-46-0,79296-54-1,97995-93-2,147731-04-2) + 4-bromo-benzaldehyde (1122-91-4) → dimethyl (hydroxy(4-bromophenyl)methyl)phosphonate (20406-39-7) + benzaldehyde (100-52-7)

Guidance literature:

With zinc trifluoromethanesulfonate; triethylamine; In chloroform-d1; for 168h; Product distribution; Ambient temperature; without either the NEt₃ or the Zn-salt and NEt₃ as well;

DOI:10.1016/S0022-328X(97)00176-9

upstream raw materials:

4-bromo-benzaldehyde

Dimethyl phosphite

dimethyl 1-hydroxy-1-phenylmethylphosphonate

phosphorous acid trimethyl ester

Downstream raw materials:

p-Brombenzoyl-dimethyl-phosphonat

1,3-bis((S)-1-phenylethyl)-1,3,2-diazaphospholidine 2-oxide