methyl 4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

• Chemical Name: methyl 4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS No.: 205999-87-7
• Molecular Formula: C14H16N2O4
• Molecular Weight: 276.292
• Mol file: 205999-87-7.mol

Synonyms:4-(4-Methoxy-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester;methyl 6-methyl-4-(4-methoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate;methyl 4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;5-(methoxycarbonyl)-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one;methyl 1,2,3,4-tetrahydro-4-(4-methoxyphenyl)-6-methyl-2-oxopyrimidine-5-carboxylate;methyl 4-(4'-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;5-(methoxycarbonyl)-6-methyl-4-(4-methoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one;

Chemical Property of methyl 4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property:

• PSA: 76.66000
• LogP: 2.15370

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 7 articles about methyl 4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-benzaldehyde (123-11-5) + acetoacetic acid methyl ester (105-45-3) + urea (57-13-6) → 5-methoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one (205999-87-7)

Guidance literature:

With sulfuric acid; copper(l) chloride; In methanol; Reflux; Inert atmosphere;

DOI:10.1021/jacs.0c11267

Reference yield: 98.0%

4-methoxybenzaldehyde semicarbazone (6292-71-3,120445-53-6) + acetoacetic acid methyl ester (105-45-3) + urea (57-13-6) → 5-methoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one (205999-87-7)

Guidance literature:

With bismuth(III) vanadate; In ethanol; for 0.833333h; Reflux;

DOI:10.1007/s13738-016-0959-y

Reference yield: 90.0%

→ 5-methoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one (205999-87-7)

Guidance literature:

With bis(cyclopentadienyl)titanium dichloride; In ethanol; at 70 ℃; for 10h;

upstream raw materials:

4-methoxy-benzaldehyde

acetoacetic acid methyl ester

urea

monocarbamide dihydrogen sulfate

Downstream raw materials:

4-(4-methoxy-phenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester

4-(4-methoxy-phenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester

C₁₅H₁₆N₂O₅