2-Methyl-4-phenyl-5-methyloxazole

Base Information

• Chemical Name: 2-Methyl-4-phenyl-5-methyloxazole
• CAS No.: 20662-92-4
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Hs Code.: 2934999090
• Mol file: 20662-92-4.mol

Synonyms:dimethyl-2,5 phenyl-4 oxazole;Oxazole,2,5-dimethyl-4-phenyl;4-phenyl-2,5-dimethyloxazole;2,5-dimethyl-4-phenyl-oxazole;2,5-Dimethyl-4-phenyl-oxazol;2,4-Dimethyl-5-phenyloxazole;2-Methyl-4-phenyl-5-methyloxazole;

Chemical Property of 2-Methyl-4-phenyl-5-methyloxazole

Chemical Property:

• Boiling Point: 255-258 °C
• PKA: 2.52±0.10(Predicted)
• PSA: 26.03000
• Density: 1.088 g/cm3(Temp: 25 °C)
• LogP: 2.95840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methyl-4-phenyl-5-methyloxazole

There total 28 articles about 2-Methyl-4-phenyl-5-methyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetonitrile (75-05-8,26809-02-9) + 1-phenyl-acetone (103-79-7,136675-26-8) → 2,5-dimethyl-4-phenyloxazole (20662-92-4)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); toluene-4-sulfonic acid; for 2h; Heating;

DOI:10.1246/cl.1983.1355

Reference yield: 95.0%

1--2-(ethanoyloxy)-1-phenyl-1-propene (141118-61-8) → 2,5-dimethyl-4-phenyloxazole (20662-92-4)

Guidance literature:

at 625 ℃; under 1 Torr;

DOI:10.1021/jo00038a020

Reference yield: 94.0%

acetamide (60-35-5) + 1-phenyl-propan-1-one (93-55-0) → 2,5-dimethyl-4-phenyloxazole (20662-92-4)

Guidance literature:

1-phenyl-propan-1-one; With hydroxy(phenyl)-λ³-iodanyl 2,4-dinitrobenzenesulfonate; for 0.0111111h; microwave irradiation;

acetamide; for 0.0333333h; microwave irradiation;

DOI:10.1016/S0040-4039(02)02493-0

upstream raw materials:

N-(2-oxo-1-phenylpropyl)acetamide

2-bromo-1-phenyl-1-propanone

phenylglycin

N-(α-phenylpropargyl)acetamide

Downstream raw materials:

5-bromomethyl-4-phenyl-2-methyloxazole

(E)-2-(2-Phenylvinyl)-4-methyl-5-phenyloxazole

(Z)-2-(2-Phenylvinyl)-4-methyl-5-phenyloxazole

N-acetylbenzamide