3-(4-Methoxyphenyl)furan

Base Information

• Chemical Name: 3-(4-Methoxyphenyl)furan
• CAS No.: 20842-11-9
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• DSSTox Substance ID: DTXSID80454204
• Nikkaji Number: J978.944H
• Wikidata: Q82275585
• Mol file: 20842-11-9.mol

Synonyms:3-(4-methoxyphenyl)furan;20842-11-9;Furan, 3-(4-methoxyphenyl)-;SCHEMBL23089965;DTXSID80454204

Chemical Property of 3-(4-Methoxyphenyl)furan

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 174.068079557
• Heavy Atom Count: 13
• Complexity: 150

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=COC=C2

Technology Process of 3-(4-Methoxyphenyl)furan

There total 15 articles about 3-(4-Methoxyphenyl)furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

furan-3-boronic acid (55552-70-0) + 4-chloromethoxybenzene (623-12-1) → 3-(4-methoxy-phenyl)-furan (20842-11-9)

Guidance literature:

With potassium phosphate tribasic trihydrate; PdCl₂(C₃H₃N₂(CH₃))(C₃H₂N₂(C₆H₃(C₃H₇)2)2); In tetrahydrofuran; water; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2011.08.042

Reference yield: 91.0%

3-bromofurane (22037-28-1) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 3-(4-methoxy-phenyl)-furan (20842-11-9)

Guidance literature:

With cobalt(II) chloride; sodium t-butanolate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In tetrahydrofuran; at 20 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0037-1609337

Reference yield: 88.0%

3-bromofurane (22037-28-1) + 4-methoxyphenylboronic acid (5720-07-0) → 3-(4-methoxy-phenyl)-furan (20842-11-9)

Guidance literature:

With C₂₀H₂₀N₂O₂Pd; sodium hydrogencarbonate; In water; at 120 ℃; for 6h;

DOI:10.1002/cjoc.201900417

upstream raw materials:

4-methoxyphenylboronic acid

4-methoxyphenyllead(IV) triacetate

tributyl(furan-3-yl)stannane

4-(4-methoxyphenyl)furan-2(5H)-one