Methyl 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate

Base Information

• Chemical Name: Methyl 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate
• CAS No.: 20845-22-1
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.164
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00492224
• Nikkaji Number: J897.972C
• Wikidata: Q82337910
• Mol file: 20845-22-1.mol

Synonyms:20845-22-1;Methyl 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate;METHYL 1-METHYL-6-OXOPYRIDINE-2-CARBOXYLATE;2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo-, methyl ester;SCHEMBL2413275;Methyl1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate;DTXSID00492224;INFQCCFXGFIXCI-UHFFFAOYSA-N;MFCD22581562;AKOS016014095;SB53439;AS-43442;CS-0080850;EN300-208558;A879392;Methyl 1-Methyl-6-oxo-1.6-dihydropyridine-2-carboxylate;Methyl 1-methyl-6-oxo-1 pound not6-dihydropyridine-2-carboxylate

Chemical Property of Methyl 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate

Chemical Property:

• Melting Point: 53-54 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 327.8±35.0 °C(Predicted)
• PKA: -1.17±0.62(Predicted)
• PSA: 48.30000
• Density: 1.227±0.06 g/cm3(Predicted)
• LogP: 0.17190
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 167.058243149
• Heavy Atom Count: 12
• Complexity: 278

Purity/Quality:

99%, ^*data from raw suppliers

Methyl1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C(=O)C=CC=C1C(=O)OC

Technology Process of Methyl 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate

There total 6 articles about Methyl 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-methoxy-pyridine-2-carboxylic acid methyl ester (26256-72-4) + methyl iodide (74-88-4) → 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid methyl ester (20845-22-1)

Guidance literature:

at 200 ℃; for 18h;

DOI:10.1039/b517462g

Reference yield: 48.0%

methyl 6-oxo-1,6-dihydropyridine-2-carboxylate (30062-34-1) + methyl iodide (74-88-4) → 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid methyl ester (20845-22-1)

Guidance literature:

With cesium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1016/j.bmc.2009.05.069

Reference yield:

6-bromo-pyridine-2-carboxylic acid (21190-87-4) → 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid methyl ester (20845-22-1)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. hydrochloric acid / 15 h / 180 °C

2: conc. sulfuric acid / 16 h / Heating

3: K₂CO₃, DMSO / 4 h / Heating

With hydrogenchloride; sulfuric acid; potassium carbonate; dimethyl sulfoxide;

upstream raw materials:

methyl iodide

6-methoxy-pyridine-2-carboxylic acid methyl ester

6-bromo-pyridine-2-carboxylic acid

6-bromopyridine-2-carbonyl chloride

Downstream raw materials:

1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid

methanol

(1S,2R,6R,7R)-8-Methyl-3,5,9-trioxo-4-phenyl-4,8-diaza-tricyclo[5.2.2.0^2,6]undec-10-ene-7-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 20845-22-1 Methyl 1-Methyl-6-oxo-1.6-dihydropyridine-2-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send