2-Chloro-4,6-bis(4-methoxyphenyl)-1,3,5-triazine

Base Information

• Chemical Name: 2-Chloro-4,6-bis(4-methoxyphenyl)-1,3,5-triazine
• CAS No.: 21902-35-2
• Molecular Formula: C17H14ClN3O2
• Molecular Weight: 327.77
• DSSTox Substance ID: DTXSID401236010
• Nikkaji Number: J2.710.884I
• Mol file: 21902-35-2.mol

Synonyms:2-chloro-4,6-bis(4-methoxyphenyl)-1,3,5-triazine;21902-35-2;SCHEMBL7801135;DDKIZZVCGFOEDF-UHFFFAOYSA-N;DTXSID401236010;1,3,5-Triazine, 2-chloro-4,6-bis(4-methoxyphenyl)-

Chemical Property of 2-Chloro-4,6-bis(4-methoxyphenyl)-1,3,5-triazine

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 327.0774544
• Heavy Atom Count: 23
• Complexity: 326

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NC(=NC(=N2)Cl)C3=CC=C(C=C3)OC

Technology Process of 2-Chloro-4,6-bis(4-methoxyphenyl)-1,3,5-triazine

There total 6 articles about 2-Chloro-4,6-bis(4-methoxyphenyl)-1,3,5-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 2-chloro-4,6-bis(4-methoxyphenyl)-1,3,5-triazine (21902-35-2)

Guidance literature:

In tetrahydrofuran; at 0 - 80 ℃; for 15h; Inert atmosphere;

Reference yield: 74.0%

1-bromo-4-methoxy-benzene (104-92-7) + 1,3,5-trichloro-2,4,6-triazine (108-77-0) → 2-chloro-4,6-bis(4-methoxyphenyl)-1,3,5-triazine (21902-35-2)

Guidance literature:

1-bromo-4-methoxy-benzene; With iodine; magnesium; In tetrahydrofuran; at 20 ℃; Reflux;

1,3,5-trichloro-2,4,6-triazine; In tetrahydrofuran; at 50 ℃; Cooling with ice;

DOI:10.1021/ol702698r

Reference yield: 67.0%

2,4-dichloro-6-(4-methoxy-phenyl)-[1,3,5]triazine (90723-86-7) + 4-methoxyphenylboronic acid (5720-07-0) → 2-chloro-4,6-bis(4-methoxyphenyl)-1,3,5-triazine (21902-35-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; toluene; at 60 ℃; for 6h; Inert atmosphere;

upstream raw materials:

1-bromo-4-methoxy-benzene

1,3,5-trichloro-2,4,6-triazine

4-methoxyphenyl magnesium bromide

4-methoxyphenylboronic acid

Downstream raw materials:

C₃₄H₂₈N₆O₄

4-(4,6-bis(4-methoxyphenyl)-1,3,5-triazin-2-yl)benzaldehyde