90723-86-7

Basic information

• Product Name: 2,4-dichloro-6-(4-methoxyphenyl)-1,3,5-triazine
• Synonyms: 2,4-dichloro-6-(4-methoxyphenyl)-1,3,5-triazine;1,3,5-Triazine,2,4-dichloro-6-(4-methoxyphenyl;2,4-dichloro-6-(4-methoxyphenyl)-
• CAS NO: 90723-86-7
• Molecular Formula: C₁₀H₇Cl₂N₃O
• Molecular Weight: 256.08808
• EINECS: 604-604-1
• Mol File: 90723-86-7.mol

Chemical Properties

• Melting Point: 132-133 °C
• Boiling Point: 457.1±47.0 °C(Predicted)
• Appearance: /
• Density: 1.404±0.06 g/cm3(Predicted)
• Solubility: Benzene, DCM, Ethyl Acetate,
• PKA: -1.37±0.10(Predicted)
• CAS DataBase Reference: 2,4-dichloro-6-(4-methoxyphenyl)-1,3,5-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-6-(4-methoxyphenyl)-1,3,5-triazine(90723-86-7)
• EPA Substance Registry System: 2,4-dichloro-6-(4-methoxyphenyl)-1,3,5-triazine(90723-86-7)

Safety Data

• Hazardous Substances Data: 90723-86-7(Hazardous Substances Data)

Usage

Uses

Used in Sunscreen Industry:
2,4-dichloro-6-(4-methoxyphenyl)-1,3,5-triazine is used as a chemical intermediate for the production of Bemotrizinol, a UV absorber that is incorporated into various sunscreens to protect the skin from harmful UV rays. Its ability to absorb both UVA and UVB rays makes it a valuable component in the formulation of effective sunscreen products.

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 100-66-3 methoxybenzene 
• 108-78-1 2,4,6-triamino-s-triazine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 73774-45-5 di-(4-methoxyphenyl)borinic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 127099-85-8 N-Cyanoguanidine 

Downstream Products

• 187393-00-6 tinosorb S 
• 1440-00-2 4-[4-(2,4-dihydroxyphenyl)-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl]benzene-1,3-diol 
• 67014-53-3 4-(4,6-bis(4-methoxyphenyl)-1,3,5-triazin-2-yl)benzaldehyde 
• 21902-35-2 2-chloro-4,6-bis(4-methoxyphenyl)-1,3,5-triazine 

Relevant articles and documents

Synthesis, characterization, and antimicrobial screening of s-triazines linked with piperazine or aniline scaffolds

Two series of s-triazines linked with piperazine or aniline scaffolds (4a-i and 5a-j) were synthesized and evaluated for their in vitro biological efficacy against Gram positive and Gram negative bacteria (Klebsiella pneumoniae MTCC 109, Pseudomonas aerug

Manufacturing method of triazine-based compound and derivative thereof

The present invention relates to a triazine-based compound and a process for producing the same. The triazine compound according to an embodiment of the present invention may be prepared by reacting cyanuric acid (Cyanuric Chloride), anisole (anisole) and resorcinol (Resorcinol) to produce a triazine-based compound represented by Formula 1. Chemical Formula 1.

Preparation method of 2,4-dichloro-6-(4-methoxyphenyl)-1,3,5-triazine

The invention discloses a preparation method of 2,4-dichloro-6-(4-methoxyphenyl)-1,3,5-triazine. According to the preparation method, p-methoxyphenylboronic acid and cyanuric chloride are taken as raw materials and a magnetic silicon dioxide supported palladium complex is taken as a catalyst, an alkali and a solvent are added, Suzuki coupling reaction is conducted, a catalyst phase is separated out after the reaction, the solvent is recovered from a product phase, and finally, recrystallizing and drying are conducted to obtain a pure product 2,4-dichloro-6-(4-methoxyphenyl)-1,3,5-triazine. The catalyst can be separated, recovered and recycled through an external magnetic field, the magnetic catalyst is high in activity, high in catalytic efficiency and high in reaction selectivity, the product purity is high, operation is simple, reaction conditions are mild, the reaciton process is clean and friendly, and the method provided by the invention is a novel green and efficient preparation method.

TRIAZINE UV ABSORBERS AND A PROCESS FOR THE PREPARATION THEREOF

The presently claimed invention relates to novel, highly efficient triazine UV absorbers and a general process for the preparation UV absorber compounds from natural precursors.

Polymerizable UV absorbers for the UV stabilization of polyesters. I. Design, synthesis and polymerization of a library of UV absorbing monomers

UV stabilizers, such as Tinuvin 1577, are organic additives that are used in the polymer industry to suppress polymer photodegradation, however leaching of the stabilizers from polymers is a significant practical issue which limits the effectiveness of the stabilizers and restricts polymer lifetimes. Novel, polymerizable UV stabilizers were synthesised and copolymerized with bis(2-hydroxyethyl) isophthalate to yield poly(ethylene isophthalate) copolymers where the UV stabilizers are bound covalently into the polymer chains. This strategy prevents leaching of stabilizers from polymers over time, and is expected to lead to enhanced UV protection of polymers compared to the admixing of polymers with UV stabilizers of low molar mass.

Method for synthesizing triazine compound by Friedel-Crafts reaction micro-channel method

The invention discloses a method for synthesizing a triazine compound by a Friedel-Crafts reaction micro-channel method. The method comprises the following steps: carrying out mixing dissolving on cyanuric chloride represented by a formula (I), a compound represented by a formula (II), a Lewis acid as a catalyst and an organic solvent to obtain a reaction solution for later use; replacing and exhausting the air in a micro-channel reactor by using nitrogen, injecting the prepared reaction liquid into the micro-channel reactor through a metering pump, carrying out a Friedel-Crafts reaction, controlling the reaction temperature to be 0-120 DEG C, controlling the reaction retention time to be 10-180 minutes, and carrying out post-treatment on the reaction liquid flowing out of the micro-channel reactor to obtain the triazine compound represented by a formula (III), wherein in the formula (II) and the formula (III), the substituent R1 is hydrogen, methyl, hydroxyl, methoxy or chlorine atom,and the substituent R2 is hydrogen, methyl or hydroxyl. By adopting the micro-channel reactor, the corresponding reaction conditions are optimized, the mass transfer and heat transfer effects of thereaction are good, the reaction time is shortened, side reactions are reduced, and the yield of the target product is high.

A new class of 1,3,5-triazine-based selective estrogen receptor degraders (SERDs): Lead optimization, molecular docking and dynamic simulation

Selective estrogen receptor degrader (SERD) that acts as not only ER antagonist, but also ER degrader, would be useful for the treatment for drug-resistance ER+ breast cancer. However, most of currently available SERD candidates involve very limited molecular scaffolds and are still in clinical trials. In this study, we introduced a 1,3,5-triazine ring into a homobibenzyl motif extracted from amounts of ER ligands and synthesized sixteen SERDs bearing acrylic acid or acrylic amide side chains that possess both ERα antagonism and degradation properties. And all compounds were screened for their anti-proliferative activity against ER+ MCF-7 and Ishikawa cell lines. Among them, compound XHA1614 displayed potent growth inhibition activity against MCF-7 and Ishikawa cells with IC50 values of 3.15 μM and 3.11 μM, respectively. Moreover, XHA1614 could dramatically degrade ER level at 1 nM in a Western blotting assay and afforded an outstanding antagonistic activity via suppressing the expression of progesterone receptor messenger RNA in MCF-7 cells in a RT-PCR assay. Further molecular docking and dynamic simulation on properly selected derivative furnished insights into its binding profile within ERα. Our findings suggest that the 1,3,5-triazine core was a feasible alternative to currently reported SERD scaffold, and provide information that will be useful for further development of promising SERDs candidates for breast cancer therapies.

IMPACT OF TRACE ELEMENTS IN THE GRIGNARD REACTION

The present invention relates to an improved process for preparing 2,4-dichloro-6-(4- methoxyphenyl)-1,3,5-triazine (DICAT) comprising reacting 4-bromoanisole with magnesium, and reacting the resulting Grignard reagent with cyanuric chloride, wherein the magnesium comprises additional metals as impurities in an amount of less than 0.027 % by weight, based on the total weight of the magnesium.

An ultraviolet absorbent the day executes S intermediate preparation method

The invention relates to an ultraviolet absorbent the day executes S intermediate preparation method, in particular to a 2, 4 - double-(2, 4 - dihydroxy-phenyl) - 6 - (methoxyphenyl) - 1, 3, 5 - triazine. The invention in step (1) in the specific catalyst, direct catalytic cyanuric chloride and anisole for carrying out the alkylation reaction, to obtain intermediate 2, 4 - dichloro - 6 - (methoxyphenyl) - 1, 3, 5 - triazine solution, then put in the resorcinol, sulfolane, catalyst, the reaction is carried out, the filter, the filtrate is hydrolyzed, separating solid, filtered and the solid water washing, drying, to obtain 2, 4 - double-(2, 4 - dihydroxy-phenyl) - 6 - (methoxyphenyl) - 1, 3, 5 - triazine. The invention atom economy high, low material cost, the production low safety risk and less environmental pollution.

Manufacturing method of triazine-based compound and derivative thereof

The present invention relates to a triazine-based compound, and a method for manufacturing derivatives thereof. The method for manufacturing the triazine-based compound according to an embodiment of the present invention can manufacture the triazine-based compound represented by chemical formula 1 by conducting a reaction of cyanuric chloride, anisole, and resorcinol. The method for manufacturing the triazine-based compound according to an embodiment of the present invention can simplify a reaction step.COPYRIGHT KIPO 2020