1-(4-Chlorophenyl)-3-[(2-nitrophenyl)methoxy]-1H-pyrazole

Base Information

• Chemical Name: 1-(4-Chlorophenyl)-3-[(2-nitrophenyl)methoxy]-1H-pyrazole
• CAS No.: 220368-29-6
• Molecular Formula: C16H12ClN3O3
• Molecular Weight: 329.743
• Mol file: 220368-29-6.mol

Synonyms:2-[1-(4-chlorophenyl)pyrazol-3-yl]oxymethylnitrobenzene;1-(4-chlorophenyl)-3-(2-nitrobenzyloxy)pyrazole;

Chemical Property of 1-(4-Chlorophenyl)-3-[(2-nitrophenyl)methoxy]-1H-pyrazole

Chemical Property:

• Boiling Point: 483.1±35.0 °C(Predicted)
• PKA: -0.39±0.10(Predicted)
• PSA: 72.87000
• Density: 1.36
• LogP: 4.53610
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly); Methanol (Slightly)

Purity/Quality:

98.0%Min ^*data from raw suppliers

1-(4-Chlorophenyl)-3-((2-nitrobenzyl)oxy)-1H-pyrazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(4-Chlorophenyl)-3-[(2-nitrophenyl)methoxy]pyrazole is an intermediate for the synthesis of Pyraclostrobin-d6 (P840402). Isotope labelled Pyraclostrobin is a fungicide for use in seed grass and food crops.

Technology Process of 1-(4-Chlorophenyl)-3-[(2-nitrophenyl)methoxy]-1H-pyrazole

There total 11 articles about 1-(4-Chlorophenyl)-3-[(2-nitrophenyl)methoxy]-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

1-(para-chlorophenyl)-3-hydroxypyrazole (76205-19-1) + 2-nitrophenylmethyl bromide (3958-60-9) → 2-[(N-4-chlorophenyl)-1H-pyrazol-3-yloxymethyl]-1-nitrobenzene (220368-29-6)

Guidance literature:

With tetrabutylammomium bromide; potassium hydroxide; In methanol; at 50 ℃; for 2h; Temperature; Large scale;

Reference yield: 96.3%

4-chlorophenylhydrazine hydrochloride (1073-70-7) + 2-nitrophenylmethyl bromide (3958-60-9) → 2-[(N-4-chlorophenyl)-1H-pyrazol-3-yloxymethyl]-1-nitrobenzene (220368-29-6)

Guidance literature:

In ethanol; at 20 ℃; Solvent;

Reference yield: 93.0%

1-(para-chlorophenyl)-3-hydroxypyrazole (76205-19-1) + 2-Chloronitrobenzene (88-73-3) → 2-[(N-4-chlorophenyl)-1H-pyrazol-3-yloxymethyl]-1-nitrobenzene (220368-29-6)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In 1,2-dichloro-ethane; chlorobenzene; at 50 ℃; for 4h; Temperature; Reagent/catalyst; Solvent;

upstream raw materials:

1-Chloro-4-iodobenzene

3-(2-nitrobenzyloxy)-1H-pyrazole

bromochlorobenzene

1-methyl-2-nitrobenzene

Downstream raw materials:

N-hydroxy-N-2-[(N-p-chlorophenyl)-3-pyrazolyloxymethyl]phenyl hydroxylamine

2-(((1-(4-chlorophenyl)-1Hpyrazol-3-yl)oxy)methyl)aniline

pyraclostrobin