4-(Trimethylsilyl)pyridine

Base Information

• Chemical Name: 4-(Trimethylsilyl)pyridine
• CAS No.: 18301-46-7
• Molecular Formula: C8H13 N Si
• Molecular Weight: 151.283
• DSSTox Substance ID: DTXSID10171376
• Nikkaji Number: J149.515A
• Wikidata: Q83041454
• Mol file: 18301-46-7.mol

Synonyms:4-(TRIMETHYLSILYL)PYRIDINE;18301-46-7;trimethyl(pyridin-4-yl)silane;Pyridine, 4-(trimethylsilyl)-;C8H13NSi;4-trimethylsilylpyridine;Pyridine,4-(trimethylsilyl)-;trimethyl(4-pyridyl)silane;4-Trimethylsilanyl-pyridine;Pyridine,4-(trimethylsilyl);SCHEMBL1460348;DTXSID10171376;PYUVWRKNVLSJJE-UHFFFAOYSA-N;MFCD11520474;AKOS006326015;A812741;J-513951

Chemical Property of 4-(Trimethylsilyl)pyridine

Chemical Property:

• Vapor Pressure: 0.595mmHg at 25°C
• Boiling Point: 195.2°Cat760mmHg
• Flash Point: 71.8°C
• PSA: 12.89000
• Density: 0.9g/cm³
• LogP: 1.62680
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 151.081725953
• Heavy Atom Count: 10
• Complexity: 100

Purity/Quality:

97% ^*data from raw suppliers

4-(Trimethylsilyl)pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)C1=CC=NC=C1

Technology Process of 4-(Trimethylsilyl)pyridine

There total 14 articles about 4-(Trimethylsilyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridine (110-86-1) + trimethylsilanide ion (54711-92-1) → 4-trimethylsilylpryridine (18301-46-7)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; for 2h;

DOI:10.1002/poc.570

Reference yield: 99.0%

pyridine (110-86-1) + 1,1,1,2,2,2-hexamethyldisilane (1450-14-2) → 4-trimethylsilylpryridine (18301-46-7)

Guidance literature:

pyridine; 1,1,1,2,2,2-hexamethyldisilane; With sodium methylate; In N,N,N,N,N,N-hexamethylphosphoric triamide; for 2h;

With water; Further stages.;

DOI:10.1021/ol015666s

Reference yield: 87.0%

pyridine (110-86-1) + 1,1,1,2,2,2-hexamethyldisilane (1450-14-2) + chloroformic acid ethyl ester (541-41-3) → 4-trimethylsilylpryridine (18301-46-7) + N-ethylformate-4-trimethylsilyl-4-hydropyridine

Guidance literature:

pyridine; 1,1,1,2,2,2-hexamethyldisilane; With sodium methylate; In N,N,N,N,N,N-hexamethylphosphoric triamide; for 0.25h;

chloroformic acid ethyl ester; Further stages.;

DOI:10.1021/ol015666s

upstream raw materials:

pyridine

chloro-trimethyl-silane

4-bromopyridin

1,4-bis(trimethylsilyl)-1-aza-2,5-cyclohexadiene

Downstream raw materials:

4-(((trimethylsilyl)oxy)(phenyl)methyl)pyridine

N-phenacyl-4-trimethylsilylpyridinium bromide

pyridine-4-carbaldehyde

4-trimethylsilylpyridinium benzoylmethylid