Benzamide, 4-methoxy-N-(phenylmethoxy)-

Base Information

• Chemical Name: Benzamide, 4-methoxy-N-(phenylmethoxy)-
• CAS No.: 22426-89-7
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.289
• DSSTox Substance ID: DTXSID20401833
• Nikkaji Number: J1.189.201I
• Wikidata: Q82205092
• ChEMBL ID: CHEMBL1563124
• Mol file: 22426-89-7.mol

Synonyms:Benzamide, 4-methoxy-N-(phenylmethoxy)-;22426-89-7;MLS001242711;CHEMBL1563124;DTXSID20401833;HMS2211O06;HMS3338N22;AKOS009024310;4-Methoxybenzohydroxamic acid benzyl ester;SMR000841518

Chemical Property of Benzamide, 4-methoxy-N-(phenylmethoxy)-

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 257.10519334
• Heavy Atom Count: 19
• Complexity: 269

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)NOCC2=CC=CC=C2

Technology Process of Benzamide, 4-methoxy-N-(phenylmethoxy)-

There total 10 articles about Benzamide, 4-methoxy-N-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

O-benzylhydoxylamine hydrochloride (2687-43-6) + 4,5-Dichloro-2-(4-methoxy-benzoyl)-2H-pyridazin-3-one (155164-68-4) → N-p-methoxybenzoyl-O-benzylhydroxylamine (22426-89-7)

Guidance literature:

With Amberlite(R) IRA-67; In acetonitrile; at 20 ℃; for 0.583333h;

DOI:10.1081/SCC-200050375

Reference yield: 95.0%

N-benzyloxyamine (622-33-3) + 4-methoxybenzoic acid (100-09-4) → N-p-methoxybenzoyl-O-benzylhydroxylamine (22426-89-7)

Guidance literature:

With phosphoric acid di-Et ester 2-phenylbenzimidazol-1-yl ester; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h;

DOI:10.1016/j.tetlet.2007.04.058

Reference yield: 89.0%

methyl 4-methoxybenzoate (121-98-2) + O-benzylhydoxylamine hydrochloride (2687-43-6) → N-p-methoxybenzoyl-O-benzylhydroxylamine (22426-89-7)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h;

DOI:10.1021/jo0509713

upstream raw materials:

benzyl bromide

potassium p-methoxylbenzohydroxamate

N-benzyloxyamine

4-methoxy-benzoyl chloride

Downstream raw materials:

O-Benzoylsulfonyl-N-benzyloxy-p-anisimidsaeure

C₁₅H₁₄BrNO₂

N-benzyloxy-N-(4-bromobenzyl)-4-methoxy-benzamide

N-(4-bromobenzyl)-4-methoxy-benzamide