(4-Fluoro-3-iodophenyl)methanol

Base Information

• Chemical Name: (4-Fluoro-3-iodophenyl)methanol
• CAS No.: 227609-87-2
• Molecular Formula: C7H6FIO
• Molecular Weight: 252.027
• Hs Code.: 2906290090
• Mol file: 227609-87-2.mol

Synonyms:4-Fluoro-3-iodobenzylalcohol;Benzenemethanol,4-fluoro-3-iodo;

Chemical Property of (4-Fluoro-3-iodophenyl)methanol

Chemical Property:

• Boiling Point: 295.6±30.0 °C(Predicted)
• PKA: 13?+-.0.10(Predicted)
• PSA: 20.23000
• Density: 1.945±0.06 g/cm3(Predicted)
• LogP: 1.92260

Purity/Quality:

99%min. ^*data from raw suppliers

4-Fluoro-3-iodobenzyl alcohol 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Fluoro-3-iodophenyl)methanol

There total 3 articles about (4-Fluoro-3-iodophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-amino-4-fluorophenyl)methanol (227609-86-1) → (4-fluoro-3-iodophenyl)methanol (227609-87-2)

Guidance literature:

(3-amino-4-fluorophenyl)methanol; With sulfuric acid; sodium nitrite;

With potassium iodide; at 60 ℃; for 2h;

DOI:10.1021/jm030356w

Reference yield:

sodium nitrite (7632-00-0) + (3-amino-4-fluorophenyl)methanol (227609-86-1) → (4-fluoro-3-iodophenyl)methanol (227609-87-2)

Guidance literature:

With potassium iodide; sulfuric acid; In water;

Reference yield:

3-amino-4-fluorobenzoic acid (2365-85-7) → (4-fluoro-3-iodophenyl)methanol (227609-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 7.0 g / BH₃*THF / tetrahydrofuran / 20 °C

2.1: H₂SO₄; aq. NaNO₂

2.2: 6.4 g / aq. KI / 2 h / 60 °C

With borane-THF; sulfuric acid; sodium nitrite; In tetrahydrofuran;

DOI:10.1021/jm030356w

upstream raw materials:

(3-amino-4-fluorophenyl)methanol

3-amino-4-fluorobenzoic acid

sodium nitrite

Downstream raw materials:

4-fluoro-3-iodobenzaldehyde

9-(4-Fluoro-3-iodophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one,1,1-dioxide

Refernces

• 1、 -. "Novel radioligands and their use for identifying potassium channel modulators". . . Retrieved 2008/06/13.
• 2、 -. "Potassium channel openers". . . Retrieved 2008/06/13.