Nitrosodium

Base Information

• Chemical Name: Nitrosodium
• CAS No.: 7632-00-0
• Molecular Formula: NaNO2
• Molecular Weight: 68.9953
• Hs Code.: 2834299090
• NSC Number: 77391
• Nikkaji Number: J2.596.628G
• Mol file: 7632-00-0.mol

Synonyms:Nitrosodium;NSC77391

Chemical Property of Nitrosodium

Chemical Property:

• Appearance/Colour: white to off-white powder
• Melting Point: 271 °C(lit.)
• Boiling Point: 320 °C
• PSA: 52.49000
• Density: 2.168 g/cm³
• LogP: 0.25060
• Water Solubility.: 820 g/L (20℃)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 69.99049756
• Heavy Atom Count: 4
• Complexity: 10.3

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s): O, T, N, Xn
• Hazard Codes: O:Oxidizing agent
• Statements: R25:; R50:; R8:
• Safety Statements: S45:; S61:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: N(=O)O.[Na+]
• Use Description: Sodium nitrite finds applications across various industries due to its diverse properties. In the food industry, it is used as a food preservative and color fixative, helping to inhibit the growth of harmful bacteria in processed meats like bacon and sausages while preserving their pink color. In the pharmaceutical sector, it can be employed as a vasodilator, helping to widen blood vessels and manage conditions like angina pectoris. Moreover, in the manufacturing of industrial chemicals, sodium nitrite plays a role in the production of dyes, lubricants, and corrosion inhibitors, contributing to various industrial processes. Its versatile functions in preserving food quality, promoting health, and aiding in chemical production highlight its significance in different fields, although its use must be carefully regulated due to potential health risks when consumed in excessive amounts.
• Chemical Properties: Sodium nitrite (NaNO2) is a water-soluble, white-yellow-colored crystalline powder.
• Uses: Food Preservative: Used to prevent food spoilage and bacterial contamination, particularly in cured meats.; Antimicrobial Agent: Inhibits the growth of aerobic and anaerobic microorganisms, including pathogens like Clostridium botulinum.; Coloring Agent: Used to develop and stabilize the color of meat products, giving them a reddish-pink cured color.; Corrosion Inhibitor: Found in antifreeze and used in various industrial applications.; Cyanide Poisoning Antidote: Used as an antidote to cyanide poisoning.; Feral Pig Population Control: Employed in some countries, like Australia, for humane control of feral pig populations.
• Safety and Health Considerations: Despite being regarded by some as a toxic food additive, sodium nitrite has been found to have therapeutic benefits in conditions associated with nitric oxide insufficiency.; Overconsumption of sodium nitrite can lead to methemoglobinemia, a potentially fatal condition where hemoglobin is oxidized to methemoglobin, reducing oxygen release.
• Role in Food Industry: Sodium nitrite is a crucial ingredient in cured meats, either added directly or generated from naturally occurring nitrate by bacterial action. It inhibits microbial growth, prevents spoilage, enhances flavor and color, and extends shelf life, contributing to food safety and quality.; The use of sodium nitrite has revolutionized the meat and poultry industry, allowing for the production of diverse products with improved safety, flavor, texture, and shelf stability.
• Health Benefits and Beyond: Sodium nitrite has recognized health benefits beyond its role in the food industry, particularly in cardiovascular medicine. It plays a vital role in preserving food safety, quality, and public health.

Technology Process of Nitrosodium

There total 129 articles about Nitrosodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nitrogen(II) oxide (10102-43-9) → nitrogen (7727-37-9) + dinitrogen monoxide (10024-97-2) + sodium nitrite (7632-00-0)

Guidance literature:

With NaOH; byproducts: H2O; at room temp.;

Reference yield:

trisodium hexanitrocobaltate(III) → cis-nitrous acid (7782-77-6) + cobalt(II) nitrate + sodium nitrite (7632-00-0)

Guidance literature:

With water; In water; byproducts: O2; Irradiation (UV/VIS); photochemical decomposition;; Kinetics;

Reference yield:

sulfuric acid (7664-93-9) → cis-nitrous acid (7782-77-6) + sodium sulfate (7757-82-6) + sodium nitrite (7632-00-0)

Guidance literature:

In water; byproducts: NO2; flow reactor, 273 K; carrier gas (Ar) for evpn. of the resulting soln.; UV-monitoring of HONO and NO2;

DOI:10.1021/jp9711712

upstream raw materials:

N,N-bis(methylsulfonyl)hydroxylamine

sodium hydroxide

Nitrogen dioxide

N-oxo-N-nitrosoamine

Downstream raw materials:

3,5-dimethoxyphenyl magnesium bromide

4-sulfamoylbenzene-1-sulfonyl chloride

nitrogen

water

Refernces

β-Nitro derivatives of iron corrolates

10.1021/ic3002459

The research focuses on the regioselective nitration of different mesotriarylcorroles to synthesize β-substituted nitrocorrole iron complexes, using two distinct methods: a two-step procedure yielding three Fe(III) nitrosyl products and a one-pot approach favoring the formation of iron nitrosyl 3,17-dinitrocorrole. The study investigates how meso-aryl substituents influence the nitration reaction's progress and products, and examines the redox reactivity of the synthesized iron nitrosyl complexes. The experiments utilized various reactants, including free-base triarylcorroles, iron chloride, and sodium nitrite, with reactions monitored by TLC and UV?vis spectrophotometry. Analyses included 1H NMR, UV?vis spectroscopy, mass spectrometry, and X-ray diffraction for structural elucidation. Electrochemical techniques such as cyclic voltammetry and spectroelectrochemistry were applied to characterize the redox properties and electron transfer sites of the synthesized compounds in dichloromethane (CH2Cl2).

2-Methoxy-4-nitrobenzenediazonium salt as a practical diazonium-transfer agent for primary arylamines via tautomerism of 1,3-diaryltriazenes: Deaminative iodination and arylation of arylamines without direct diazotization

10.1246/bcsj.78.1654

The research explores the use of 2-methoxy-4-nitrobenzenediazonium salt as a diazonium-transfer agent for primary arylamines. The study investigates the tautomerism of 1,3-diaryltriazenes derived from this diazonium salt and primary arylamines, demonstrating that the introduction of a 2-methoxy-4-nitrophenyl group can effectively control the tautomerism, allowing selective utilization of one of the isomers for organic synthesis. Key chemicals involved in the research include 2-methoxy-4-nitrophenylamine, sodium nitrite, hydrochloric acid, sodium iodide, boron trifluoride, arylboronic acids, and silyl enol ethers. The research highlights the deaminative iodination and palladium-catalyzed arylation of arylamines without direct diazotization, showcasing the practical utility of the diazonium salt in these transformations. The study also involves the recovery of the starting 2-methoxy-4-nitrophenylamine after the reactions, emphasizing the sustainability and efficiency of the proposed synthetic methods.

3α-Acetoxy-6,6-dimethylbicyclo[3.1.1]heptane-2-spiro-1′- cyclopropane from nopylamine deamination

10.1039/a707911g

The study investigates the deamination of nopylamine hydrochloride using sodium nitrite in acetic acid, resulting in the formation of several products including nopyl chloride, nopyl acetate, 2-(1-acetoxyethyl)-6,6-dimethylbicyclo[3.1.1]hept-2-ene, and 3-acetoxy-6,6-dimethylbicyclo[3.1.1]heptane-2-spiro-1-cyclopropane. The researchers also compared this reaction with the acetolysis of nopyl toluene-p-sulfonate, which primarily yields 8,8-dimethyltricyclo[4.2.1.03,7]nonan-6-ol. The study explores the mechanisms behind these reactions, suggesting that the difference in products results from the transition state being reached early in deamination and late in toluene-p-sulfonate acetolysis. The researchers used various techniques such as GLC, NMR, and mass spectrometry to identify and characterize the products, providing insights into the reaction pathways and the influence of different leaving groups on the reaction outcomes.

4-((Aminooxy) methyl)) thiazole dihydrochloride.

10.1021/jm00272a031

The research focuses on the synthesis and characterization of new chemical compounds with potential applications in medicinal chemistry. The primary purpose of the study is to develop and analyze novel compounds that may have therapeutic properties or serve as intermediates in the production of pharmaceuticals. The researchers synthesized compounds such as 2-fluoro-9-(p-D-ribofuranosyl)purine (2a) and 9-(2,3,5-tri-O-acetyl-α-D-ribofuranosyl)-2-fluoropurine (2b), using various chemical reagents and techniques. Key chemicals involved in the synthesis include Raney nickel, ethanol, hydrofluoric acid, sodium nitrite, and acetic anhydride, among others. The conclusions drawn from the study highlight the successful synthesis of the target compounds and their structural confirmation through analytical techniques. The research contributes to the field of medicinal chemistry by providing new compounds that can be further explored for their biological activities and potential applications in drug development.