154348-08-0

Basic information

• Product Name: tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate
• Synonyms: tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate;2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 1-oxo-, 1,1-diMethylethyl ester;1-Oxo-2-oxa-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester
• CAS NO: 154348-08-0
• Molecular Formula: C₁₃H₂₁NO₄
• Molecular Weight: 255.312
• Mol File: 154348-08-0.mol

Chemical Properties

• Boiling Point: 399.578°C at 760 mmHg
• Flash Point: 195.458°C
• Appearance: /
• Density: 1.163g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.511
• PKA: -0.82±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate(154348-08-0)
• EPA Substance Registry System: tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate(154348-08-0)

Safety Data

• Hazardous Substances Data: 154348-08-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new drug molecules with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate serves as a valuable building block for the construction of more complex organic molecules. Its versatility in reactions makes it a useful component in the synthesis of a wide range of chemical products.
Used in Materials Science:
Tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate is utilized as a component in the development of new materials with specific properties. Its incorporation into material compositions can lead to advancements in areas such as polymer science, nanotechnology, and material engineering.

InChI:InChI=1/C13H21NO4/c1-12(2,3)18-11(16)14-7-4-13(5-8-14)6-9-17-10(13)15/h4-9H2,1-3H3

Upstream product

• 75-21-8 oxirane 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 1126-09-6 4-carbethoxypiperidine 
• 374822-47-6 1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 146603-99-8 1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate 
• 247133-32-0 4-ethoxycarbonyl-4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 176-69-2 2-oxa-8-azaspiro[4.5]decane 
• 374794-96-4 1,1-dimethylethyl 2-oxa-8-azaspiro[4,5]decane-8-carboxylate 
• 374791-95-4 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide 
• 374791-95-4 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide 
• 236406-38-5 1,1-dimethylethyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate 
• 4427-25-2 2-oxa-8-aza-spiro[4.5]decan-1-one 
• 374794-97-5 4-(2-hydroxy-ethyl)-4-(1-hydroxy-1-methyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Cyclohexane derivatives and their use as therapeutic agents

The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R17, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

Cyclohexyl derivatives and their use as therapeutic agents

The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R?17, R18, R19, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

4,4-Disubstituted cyclohexylamine NK1 receptor antagonists II

A series of novel 4,4-disubstituted cyclohexylamines as NK1 receptor antagonists is described: modifications to the amine moiety retain NK1 receptor binding affinity whilst disrupting IKr affinity.

Synthesis and pharmacological evaluation of a new class of 2-oxo-8- azaspiro (4,5)decan-1-ones as analogues of the muscarinic agonist RS-86

A new series of 8-substituted-2-oxo-8-azapsiro (4,5)decan-1-ones has been synthesized and compounds tested for their cholinergic properties in comparison with the muscarinic agonist RS-86. Preliminary in vitro and in vivo pharmacological data indicate that none of them is provided with significant cholinergic effects either at central or peripheral level. A possible explanation for the lack of activity is given on the basis of conformational studies.