4-Pyridinamine, 2-methyl-, 1-oxide

Base Information

• Chemical Name: 4-Pyridinamine, 2-methyl-, 1-oxide
• CAS No.: 14045-17-1
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• Mol file: 14045-17-1.mol

Synonyms:

Chemical Property of 4-Pyridinamine, 2-methyl-, 1-oxide

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinamine, 2-methyl-, 1-oxide

There total 7 articles about 4-Pyridinamine, 2-methyl-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

2-methyl-4-nitropyridine N-oxide (5470-66-6) → 3-methyl-4-pyridinamine (18437-58-6) + 4-methoxy-2-methylpyridine (24103-75-1) + 4-amino-2-methylpyridine N-oxide (14045-17-1) + 4,4'-azo-bis-(2,2'-dimethylpyridine) (100421-65-6)

Guidance literature:

With hydrogen; nickel on kieselguhr; In methanol; at 120 ℃; for 0.5h; under 98800.1 Torr; Further byproducts given. Yields of byproduct given;

Reference yield: 86.5%

2-methyl-4-nitropyridine N-oxide (5470-66-6) → 3-methyl-4-pyridinamine (18437-58-6) + 4-methoxy-2-methylpyridine (24103-75-1) + 4-amino-2-methylpyridine N-oxide (14045-17-1) + 4,4'-azo-2-methylpyridine N,N'-dioxide (106882-31-9) + 4,4'-azo-bis-(2,2'-dimethylpyridine) (100421-65-6)

Guidance literature:

With hydrogen; nickel on kieselguhr; In methanol; at 120 ℃; for 0.5h; under 98800.1 Torr; Product distribution; other catalysts, other solvents, other temperatures, other pressures;

Reference yield:

2-methyl-4-nitropyridine N-oxide (5470-66-6) → 3-methyl-4-pyridinamine (18437-58-6) + 4-methoxy-2-methylpyridine (24103-75-1) + 4-amino-2-methylpyridine N-oxide (14045-17-1) + 4,4'-azo-2-methylpyridine N,N'-dioxide (106882-31-9)

Guidance literature:

With hydrogen; nickel on kieselguhr; In methanol; at 120 ℃; for 0.5h; under 98800.1 Torr; Yield given. Further byproducts given. Yields of byproduct given;

upstream raw materials:

2-methyl-4-nitropyridine N-oxide

water

ethanol

hydrazine hydrate

Downstream raw materials:

3-methyl-4-pyridinamine

2-(2,4-Dimethoxy-benzylsulfanyl)-N-(2-methyl-1-oxy-pyridin-4-yl)-nicotinamide

Acetic acid 4-{[2-(2,4-dimethoxy-benzylsulfanyl)-pyridine-3-carbonyl]-amino}-pyridin-2-ylmethyl ester

Pentanoic acid 4-{[2-(2,4-dimethoxy-benzylsulfanyl)-pyridine-3-carbonyl]-amino}-pyridin-2-ylmethyl ester

Refernces

• 1、 Ovchinnikov, V. G.,Litvinenko, G. S.,Maksimenko, N. M.,Sherstyuk, A. I.,Levkov, V. A.. "CATALYTIC HYDROGENATION OF 4-NITRO-2-METHYLPYRIDINE N-OXIDE". . p. 1460 - 1468. Retrieved 2007/10/02.