4-Benzyloxy-N-methoxy-N-methylphenylacetamide

Base Information

Chemical Name:4-Benzyloxy-N-methoxy-N-methylphenylacetamide
CAS No.:243641-09-0
Molecular Formula:C17H19NO3
Molecular Weight:285.343
Hs Code.:
DSSTox Substance ID:DTXSID10460292
Wikidata:Q82284293
Mol file:243641-09-0.mol

Synonyms:4-Benzyloxy-N-methoxy-N-methylphenylacetamide;243641-09-0;SCHEMBL2353230;DTXSID10460292;NFZWIMOIORHGEH-UHFFFAOYSA-N;2-(4-benzyloxy-phenyl)-N-methoxy-N-methyl-acetamide;2-[4-(benzyloxy)phenyl]-n-methoxy-n-methylacetamide

Suppliers and Price of 4-Benzyloxy-N-methoxy-N-methylphenylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-Benzyloxy-N-methoxy-N-methylphenylacetamide

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:285.13649347
Heavy Atom Count:21
Complexity:307

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C(=O)CC1=CC=C(C=C1)OCC2=CC=CC=C2)OC

Technology Process of 4-Benzyloxy-N-methoxy-N-methylphenylacetamide

There total 4 articles about 4-Benzyloxy-N-methoxy-N-methylphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 6547-53-1
2-[4-(benzyloxy)benzyl]acetic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 243641-09-0
2-[4-(Benzyloxy)phenyl]-N-methoxy-N-methylacetamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;
DOI:10.1055/s-2000-6414

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 243641-09-0
2-[4-(Benzyloxy)phenyl]-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / K₂CO₃ / dimethylformamide / 72 h / 80 °C

2: 85 percent / aq. KOH / methanol; tetrahydrofuran / 20 °C

3: 82 percent / TBTU; DIEA / acetonitrile / 20 °C

With potassium hydroxide; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; 1: Etherification / 2: Hydrolysis / 3: Acylation;
DOI:10.1055/s-2000-6414

Reference yield:

: 58609-13-5
4-(benzyloxy)phenylacetic acid benzyl ester

: 243641-09-0
2-[4-(Benzyloxy)phenyl]-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / aq. KOH / methanol; tetrahydrofuran / 20 °C

2: 82 percent / TBTU; DIEA / acetonitrile / 20 °C

With potassium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; acetonitrile; 1: Hydrolysis / 2: Acylation;
DOI:10.1055/s-2000-6414