2-Propenoic acid, 3-(2-methylphenyl)-, ethyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(2-methylphenyl)-, ethyl ester, (2E)-
• CAS No.: 24393-48-4
• Molecular Formula: C12H14O2
• Molecular Weight: 190.242
• Mol file: 24393-48-4.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 3-(2-methylphenyl)-, ethyl ester, (2E)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, 3-(2-methylphenyl)-, ethyl ester, (2E)-

There total 57 articles about 2-Propenoic acid, 3-(2-methylphenyl)-, ethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-3-(2-methylphenyl)acrylic acid (939-57-1,2373-76-4,41397-71-1) + ethyl iodide (75-03-6) → ethyl trans-2-methylcinnamate (24393-48-4)

Guidance literature:

(E)-3-(2-methylphenyl)acrylic acid; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

ethyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1055/s-0039-1690006

Reference yield: 97.0%

ethyl potassium malonate (6148-64-7) + 2-methylphenyl aldehyde (529-20-4) → ethyl trans-2-methylcinnamate (24393-48-4)

Guidance literature:

With piperidine; dmap; acetic acid; In N,N-dimethyl-formamide; at 0 - 60 ℃; optical yield given as %de; diastereoselective reaction;

DOI:10.1016/j.tetasy.2011.06.004

Reference yield: 97.0%

2-methylphenyl bromide (95-46-5) + ethyl acrylate (140-88-5,9003-32-1) → 2-methyl-cinnamic acid ethyl ester (24393-48-4,16366-23-7)

Guidance literature:

With potassium phosphate; [((ferrocenyl)(C(CH₃)N(C₆H₄)CH₃))PdCl(N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)]; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 140 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.tet.2010.04.040

upstream raw materials:

ethanol

(E)-3-(2-methylphenyl)acrylic acid

ortho-toluoyl chloride

ethyl acrylate

Downstream raw materials:

ethyl (E)-3-[2-(bromomethyl)phenyl]-2-propenoate

(E)-3-(2-methylphenyl)acrylic acid

2-naphthylethylene

benzo[c]fluorene