3-Phenyl-2-propynyldimethylamine

Base Information

• Chemical Name: 3-Phenyl-2-propynyldimethylamine
• CAS No.: 2568-65-2
• Molecular Formula: C11H13N
• Molecular Weight: 159.231
• Mol file: 2568-65-2.mol

Synonyms:3-phenyl-prop-2-ynyl-NN-dimethylamine;2-Propyn-1-amine,N,N-dimethyl-3-phenyl;N,N-dimethyl-3-phenyl-2-propyn-1-amine;3-Phenyl-2-propynyldimethylamine;N,N-dimethylamino-3 phenyl-1 propyne-1;

Chemical Property of 3-Phenyl-2-propynyldimethylamine

Chemical Property:

• PSA: 3.24000
• LogP: 1.59970

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Phenyl-2-propynyldimethylamine

There total 24 articles about 3-Phenyl-2-propynyldimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N-Dimethylpropargylamin (7223-38-3) + iodobenzene (591-50-4) → N,N-dimethyl-3-phenyl-2-propyn-1-amine (2568-65-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N,N,N',N'-tetramethylguanidine; at 30 ℃; for 1h; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.orglett.0c01269

Reference yield: 96.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + dimethyl amine (124-40-3) + phenylacetylene (536-74-3) → N,N-dimethyl-3-phenyl-2-propyn-1-amine (2568-65-2)

Guidance literature:

With C₂₇H₄₇AgN₃Si₃⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); In neat (no solvent); at 100 ℃; for 0.25h; Catalytic behavior; Inert atmosphere; Sealed tube; Microwave irradiation;

DOI:10.1021/acs.organomet.1c00083

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N,N-dimethylammonium chloride (506-59-2) + phenylacetylene (536-74-3) → N,N-dimethyl-3-phenyl-2-propyn-1-amine (2568-65-2)

Guidance literature:

With potassium hydrogencarbonate; copper(l) iodide; In water; dimethyl sulfoxide; at 30 ℃; for 10h;

DOI:10.1016/j.tetlet.2004.09.079

upstream raw materials:

formaldehyd

dimethyl amine

phenylacetylene

4,4-dimethyl-3-dimethylamino-1-phenylhex-5-en-1-yne

Downstream raw materials:

cis-but-2-enyldimethyl-(3-phenylprop-2-ynyl)ammonium bromide

trans-but-2-enyldimethyl-(3-phenylprop-2-ynyl)ammonium bromide

(9-fluorenyl)dimethyl-(3-phenylprop-2-ynyl)ammonium bromide

dimethyl-(2-phenylallyl)-(3-phenylprop-2-ynyl)ammonium bromide

Refernces

• 1、 Sirlin, Claude,Chengebroyen, Jaganaiden,Konrath, Renato,Ebeling, Guenther,Raad, Imad,Dupont, Jairton,Paschaki, Marie,Kotzyba-Hibert, Florence,Harf-Monteil, Colette,Pfeffer, Michel. "Molecular library obtained by allene insertion into the Pd-C bond of cyclopalladated complexes: Biological and pharmacological evaluation". . p. 1724 - 1731. Retrieved 2004.
• 2、 Han, Lu,Li, Sheng-Jun,Zhang, Xue-Ting,Tian, Shi-Kai. "Aromatic Aza-Claisen Rearrangement of Arylpropargylammonium Salts Generated in situ from Arynes and Tertiary Propargylamines". supporting information. p. 3091 - 3097. Retrieved 2021/01/21.
• 3、 Afshari, Ronak,Emad Hooshmand, Seyyed,Atharnezhad, Mojtaba,Shaabani, Ahmad. "An insight into the novel covalent functionalization of multi-wall carbon nanotubes with pseudopeptide backbones for palladium nanoparticles immobilization: A versatile catalyst towards diverse cross-coupling reactions in bio-based solvents". . . Retrieved 2019/11/26.