ethyl 4-[(dimethylamino)methyl]-5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylate

Base Information

• Chemical Name: ethyl 4-[(dimethylamino)methyl]-5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylate
• CAS No.: 25913-94-4
• Molecular Formula: C16H22N2O3
• Molecular Weight: 290.35700
• Mol file: 25913-94-4.mol

Synonyms:4-dimethylaminomethyl-5-hydroxy-1,2-dimethyl-indole-3-carboxylic acid ethyl ester;4-Dimethylaminomethyl-5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylic acid ethyl ester;1,2-Dimethyl-3-ethoxycarbonyl-4-dimethylaminomethyl-5-hydroxy-indol;

Chemical Property of ethyl 4-[(dimethylamino)methyl]-5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylate

Chemical Property:

• PSA: 54.70000
• LogP: 2.43060

Purity/Quality:

ETHYL 4-[(DIMETHYLAMINO)METHYL]-5-HYDROXY-1,2-DIMETHYL-1H-INDOLE-3-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-[(dimethylamino)methyl]-5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylate

There total 1 articles about ethyl 4-[(dimethylamino)methyl]-5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + mecarbinate (15574-49-9) + dimethyl amine (124-40-3) → 4-dimethylaminomethyl-3-ethoxycarbonyl-5-hydroxy-1,2-dimethylindole (25913-94-4)

Guidance literature:

formaldehyd; mecarbinate; dimethyl amine; In ethanol; water; at 50 ℃;

With hydrogenchloride; ethanol; at 5 ℃; Further stages.;

DOI:10.1021/jm011116o

Reference yield: 71.0%

4-dimethylaminomethyl-3-ethoxycarbonyl-5-hydroxy-1,2-dimethylindole (25913-94-4) + methyl benzimidate (7471-86-5) → ethyl 7,8-dimethyl-3-phenyl-1,7-dihydro[1,3]oxazino[5,6-e]indole-9-carboxylate

Guidance literature:

In N,N-dimethyl-formamide; for 2h; Reflux;

DOI:10.1021/acs.joc.8b00692

Reference yield: 33.0%

N-(4-nitrobenzyl)pyridinium bromide (4329-73-1) + 4-dimethylaminomethyl-3-ethoxycarbonyl-5-hydroxy-1,2-dimethylindole (25913-94-4) → ethyl 6,7-dimethyl-2-(4-nitrophenyl)-1,6-dihydro-2H-furo[3,2-e]indole-8-carboxylate

Guidance literature:

In N,N-dimethyl-formamide; for 5h; Reflux; Inert atmosphere;

DOI:10.1021/jo400621r

upstream raw materials:

formaldehyd

mecarbinate

dimethyl amine

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