bis(4-methoxyphenyl)acetonitrile

Base Information

• Chemical Name: bis(4-methoxyphenyl)acetonitrile
• CAS No.: 6275-26-9
• Molecular Formula: C16H15 N O2
• Molecular Weight: 253.301
• Mol file: 6275-26-9.mol

Synonyms:Acetonitrile,bis(p-methoxyphenyl)- (6CI,7CI,8CI); (4,4'-Dimethoxydiphenyl)acetonitrile;Bis(4-methoxyphenyl)acetonitrile; Di-p-anisylacetonitrile; NSC 33422

Chemical Property of bis(4-methoxyphenyl)acetonitrile

Chemical Property:

• Vapor Pressure: 1.25E-06mmHg at 25°C
• Boiling Point: 400.7°C at 760 mmHg
• Flash Point: 143.5°C
• Density: 1.113g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of bis(4-methoxyphenyl)acetonitrile

There total 17 articles about bis(4-methoxyphenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trimethylsilyl cyanide (7677-24-9) + 4,4'-Dimethoxybenzhydrol (728-87-0) → 2,2-bis(4-methoxyphenyl)acetonitrile (6275-26-9)

Guidance literature:

With zinc trifluoromethanesulfonate; In nitromethane; at 100 ℃; for 5h;

DOI:10.1016/j.tetlet.2012.08.021

Reference yield: 85.0%

phosphoric acid (cyano)(4-methoxyphenyl)methyl ester diethyl ester + methoxybenzene (100-66-3) → 2,2-bis(4-methoxyphenyl)acetonitrile (6275-26-9)

Guidance literature:

With iron(III) trifluoromethanesulfonate; In nitromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1039/d1cc00765c

Reference yield: 82.0%

4-methoxymandelonitrile (33646-40-1) + methoxybenzene (100-66-3) → 2,2-bis(4-methoxyphenyl)acetonitrile (6275-26-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 7h; Inert atmosphere;

DOI:10.1002/anie.202013180

upstream raw materials:

pyridine

tetrakis-(4-methoxy-phenyl)-succinonitrile

phenylhydrazine

4-methoxymandelonitrile

Downstream raw materials:

4,4-bis-(4-methoxy-phenyl)-hexan-3-one

2,2-bis-(4-methoxyphenyl)acetic acid

2,2-bis-(4-methoxy-phenyl)-thioacetamide

4'-methoxy-2,2-bis(p-methoxyphenyl)acetophenone