1768-64-5 Usage
Uses
Used in Organic Synthesis:
4-Chlorotetrahydropyran is used as a starting material for various organic synthesis processes due to its reactivity and versatility in forming different chemical compounds.
Used in the Synthesis of 3-Chlorogutaric Acid:
In the chemical industry, 4-chlorotetrahydropyran is used as a reagent in the synthesis of 3-chlorogutaric acid, which is an important intermediate in the production of various pharmaceuticals and other chemical products.
Used in Photo-Catalyzed Cross-Electrophile Coupling:
4-Chlorotetrahydropyran is also utilized in the synthetic preparation of coupling products through iridium photo-catalyzed cross-electrophile coupling, a method that allows for the formation of new chemical bonds and the creation of complex molecules.
Synthesis Reference(s)
The Journal of Organic Chemistry, 54, p. 2748, 1989 DOI: 10.1021/jo00272a055Tetrahedron Letters, 25, p. 2653, 1984 DOI: 10.1016/S0040-4039(01)81254-5
Check Digit Verification of cas no
The CAS Registry Mumber 1768-64-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,6 and 8 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1768-64:
(6*1)+(5*7)+(4*6)+(3*8)+(2*6)+(1*4)=105
105 % 10 = 5
So 1768-64-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H9ClO/c6-5-1-3-7-4-2-5/h5H,1-4H2
1768-64-5Relevant academic research and scientific papers
Bunnelle, W. H.,Seamon, D. W.,Mohler, D. L.,Ball, T. F.,Thompson, D. W.
, p. 2653 - 2654 (1984)
Ethyl vinyl ether, MEM chloride, and dihydropyran based acetals of homoallylic and homopropargylic alcohols cyclize in the presence of Lewis acids to give 4-halotetrahydropyrans and 4-halo-5,6-dihydro-2H-pyrans, respectively.
HIGH YIELD PREPARATION OF 2,3,3-TRICHLORINATED TETRAHYDROPYRAN WITH AN EXCESS OF REFLUXING SULFURYL CHLORIDE IN THE DARK
Buyck, Laurent de
, p. 303 - 306 (2007/10/02)
The chlorination of tetrahydropyran with an excess of refluxing sulfuryl chloride in the dark provided 2,3,3-trichlorotetrahydropyran in 94percent isolated yield, showing evidence for a very selective non-homolytic mechansims, probably involving hydride abstraction as the first step.
