2-Propenoic acid, 3-(4-hydroxy-3-Methoxyphenyl)-, ethyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(4-hydroxy-3-Methoxyphenyl)-, ethyl ester, (2E)-
• CAS No.: 28028-62-8
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 28028-62-8.mol

Synonyms:ethyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate;ferulic acid ethyl ester;ETHYL 3-(4-HYDROXY-3-METHOXYPHENYL)ACRYLATE;ethyl ferulate;4-hydroxy-3-methoxy ethyl cinnamate;4-hydroxy-3-methoxycinnamic acid ethyl ester;

Chemical Property of 2-Propenoic acid, 3-(4-hydroxy-3-Methoxyphenyl)-, ethyl ester, (2E)-

Chemical Property:

• PSA: 55.76000
• LogP: 1.97710

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Ethyl(E)-ferulate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-(4-hydroxy-3-Methoxyphenyl)-, ethyl ester, (2E)-

There total 10 articles about 2-Propenoic acid, 3-(4-hydroxy-3-Methoxyphenyl)-, ethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(4-hydroxy-3-methoxyphenyl)acrylic acid (1135-24-6,537-98-4) + ethanol (64-17-5) → ethyl ferulate (28028-62-8,74257-26-4,4046-02-0)

Guidance literature:

at 50 ℃; for 76h;

Reference yield: 97.0%

vanillin (121-33-5,8014-42-4) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → ethyl ferulate (28028-62-8,74257-26-4,4046-02-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 4h;

DOI:10.1039/c0ob00137f

Reference yield: 97.0%

C18H28O4Si (1227148-49-3) → ethyl ferulate (28028-62-8,74257-26-4,4046-02-0)

Guidance literature:

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 20 ℃; for 0.0166667h; chemoselective reaction;

DOI:10.1016/j.cclet.2009.11.049

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

vanillin

3-(4-hydroxy-3-methoxyphenyl)acrylic acid

ethanol

Downstream raw materials:

ethyl 3-(4-hydroxy-3-methoxyphenyl)propanoate

coniferol

ethyl 3-[4-(3,4,5-triacetyloxybenzoyloxy)-3-methoxyphenyl]-2-propenoate

(E)-coniferyl ethyl ether