(R)-2-(1-HYDROXYETHYL)PYRIDINE

Base Information

• Chemical Name: (R)-2-(1-HYDROXYETHYL)PYRIDINE
• CAS No.: 27911-63-3
• Molecular Formula: C7H9NO
• Molecular Weight: 123.155
• Hs Code.: 29333990
• Mol file: 27911-63-3.mol

Synonyms:2-Pyridinemethanol,a-methyl-, (R)-;(R)-(+)-2-(1-Hydroxyethyl)pyridine;(R)-1-(2-Pyridyl)ethanol;(R)-1-(Pyridin-2-yl)ethanol;(R)-2-(1-Hydroxyethyl)pyridine;(R)-Alpha-Methyl-2-pyridinemethanol;(R)-a-Methyl-2-pyridinemethanol;(αR)-a-Methyl-2-pyridinemethanol;(1R)-1-(pyridin-2-yl)ethanol;(1R)-1-pyridin-2-ylethanol;2-pyridinemethanol, α-methyl-, (alphaR)-;

Chemical Property of (R)-2-(1-HYDROXYETHYL)PYRIDINE

Chemical Property:

• Appearance/Colour: white crystals
• Vapor Pressure: 0.113mmHg at 25°C
• Refractive Index: n20/D 1.528
• Boiling Point: 210.6 °C at 760 mmHg
• PKA: 13.55±0.20(Predicted)
• Flash Point: 81.2 °C
• PSA: 33.12000
• Density: 1.082 g/cm³
• LogP: 1.13490
• Storage Temp.: 2-8°C
• Water Solubility.: Soluble in ethanol and water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1R)?-?1-?(2-?Pyridinyl)?ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xn
• Statements: 22-37/38-41-36/37/38
• Safety Statements: 26-39-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: (1R)?-?1-?(2-?Pyridinyl)?ethanol is a building block used in the synthesis of highly potent and selective chiral inhibitors of PDE5.

Technology Process of (R)-2-(1-HYDROXYETHYL)PYRIDINE

There total 36 articles about (R)-2-(1-HYDROXYETHYL)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridine-2-carbaldehyde (1121-60-4) + methylmagnesium bromide (75-16-1) → 1-(pyridine-2-yl)ethanol (20988-55-0,18728-61-5,27911-63-3,59042-90-9)

Guidance literature:

In diethyl ether; at 0 ℃; for 2h;

DOI:10.1021/jo971521g

Reference yield: 81.0%

2-(1-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)ethyl)pyridine → 1-(pyridine-2-yl)ethanol (20988-55-0,18728-61-5,27911-63-3,59042-90-9)

Guidance literature:

With silica gel; In ethyl acetate; Petroleum ether;

DOI:10.1021/acs.organomet.8b00700

Reference yield: 79.0%

2-bromo-pyridine (109-04-6) + acetaldehyde (75-07-0,9002-91-9) → 1-(pyridine-2-yl)ethanol (20988-55-0,18728-61-5,27911-63-3,59042-90-9)

Guidance literature:

2-bromo-pyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 2h;

acetaldehyde; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(99)00789-3

upstream raw materials:

pyridine-2-carbaldehyde

methyl magnesium iodide

n-butyllithium

trimethyltelluronium iodide

Downstream raw materials:

1-(pyridin-2-yl)ethyl benzoate

P(C₆H₅)2OCH(CH₃)C₅H₄N

P(C₆H₄CH₃)2OCH(CH₃)C₅H₄N

Ethyl 4-(1-pyridin-2-ylethoxy)benzenecarboxylate

Refernces

• 1、 Newar, Rajashree,Akhtar, Naved,Antil, Neha,Kumar, Ajay,Shukla, Sakshi,Begum, Wahida,Manna, Kuntal. "Amino Acid-Functionalized Metal-Organic Frameworks for Asymmetric Base–Metal Catalysis". supporting information. p. 10964 - 10970. Retrieved 2021/03/29.
• 2、 Sahoo, Rajata Kumar,Mahato, Mamata,Jana, Achintya,Nembenna, Sharanappa. "Zinc Hydride-Catalyzed Hydrofuntionalization of Ketones". . p. 11200 - 11210. Retrieved 2020/10/12.