2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)-

Base Information

• Chemical Name: 2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)-
• CAS No.: 288385-99-9
• Molecular Formula: C10H10FNO4
• Molecular Weight: 227.192
• Mol file: 288385-99-9.mol

Synonyms:1-(2-fluoro-3-methoxy-6-nitrophenyl)-propan-2-one;3-acetylmethyl-2-fluoro-1-methoxy-4-nitrobenzene;

Chemical Property of 2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 347.933oC at 760 mmHg
• Flash Point: 164.224oC
• PSA: 72.12000
• Density: 1.291g/cm3
• LogP: 2.39720
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

1-(2-Fluoro-3-methoxy-6-nitrophenyl)propan-2-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)-

There total 5 articles about 2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,2-difluoro-3-(2,2-dimethoxypropyl)-4-nitrobenzene (288385-96-6) → 1-(2-fluoro-3-methoxy-6-nitrophenyl)propan-2-one (288385-99-9)

Guidance literature:

With hydrogenchloride; sodium methylate; sodium; In tetrahydrofuran; methanol;

Reference yield: 71.0%

1-(2,3-difluoro-6-nitrophenyl)propan-2-one (121247-16-3) → 1-(2-fluoro-3-methoxy-6-nitrophenyl)propan-2-one (288385-99-9)

Guidance literature:

With potassium carbonate; In methanol; for 3h; Heating / reflux;

Reference yield:

methanol (67-56-1) + 1-(2,3-difluoro-6-nitrophenyl)propan-2-one (121247-16-3) → 1-(2-fluoro-3-methoxy-6-nitrophenyl)propan-2-one (288385-99-9)

Guidance literature:

With potassium carbonate; at 9 - 25 ℃; for 18.8333h; Reflux; Large scale;

DOI:10.1021/op400242j

upstream raw materials:

1-(2,3-difluoro-6-nitrophenyl)propan-2-one

1,2-difluoro-3-(2,2-dimethoxypropyl)-4-nitrobenzene

2,3,4-trifluoronitrobenzene

methanol

Downstream raw materials:

1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one

2-methyl-4-fluoro-5-methoxy-1H-indole

4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester

4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol

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