- Proline
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Cas Database |
| Name |
Proline |
EINECS | 206-452-7 |
| CAS No. | 344-25-2 | Density | 1.186 g/cm3 |
| PSA | 49.33000 | LogP | 0.15180 |
| Solubility | Soluble in water | Melting Point |
223 °C (dec.)(lit.) |
| Formula | C5H9NO2 | Boiling Point | 252.2 °C at 760 mmHg |
| Molecular Weight | 225.168 | Flash Point | 106.3 °C |
| Transport Information | N/A | Appearance | White to off-white powder |
| Safety | 22-24/25-36/37/39-26 | Risk Codes | 22-36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xn,  Xi
|
| Synonyms |
D-Prolin;(R)-pyrrolidine-2-carboxylic acid;D-Proline;(2R)-pyrrolidine-2-carboxylic acid;H-D-Pro-OH;D-(+)-Proline; D-Pyrrolidine-2-carboxylic acid;D-(+)-proline;D-Pyrrolidine-2-carboxylic acid;D-Proline (Food Grade); |
Article Data | 44 |
Proline Synthetic route
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In methanol under 760 Torr; for 5h; | 96% |
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
- 344-25-2
D-Prolin
| Conditions | Yield |
|---|---|
| With potassium permanganate In water at 15 - 20℃; Concentration; | 95.65% |
- 344-25-2
D-Prolin
| Conditions | Yield |
|---|---|
| With hydrogen; palladium(II) hydroxide In tetrahydrofuran; methanol at 20℃; for 3h; | 83% |
| With hydrogen; palladium(II) hydroxide In tetrahydrofuran; methanol at 20℃; for 3h; | 83% |
- 344-25-2
D-Prolin
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In methanol | 77% |
- 143492-63-1
(R)-N-(3,5-dinitrobenzoyl)proline
- 344-25-2
D-Prolin
| Conditions | Yield |
|---|---|
| With hydrogenchloride | |
| With hydrogenchloride |
- 119838-25-4
(2R,5R)-2-t-butyl-1-t-butyloxycarbonyl-5-(3-chloropropyl)-3-methyl-4-imidazolidinone
- 344-25-2
D-Prolin
| Conditions | Yield |
|---|---|
| Yield given. Multistep reaction; |
- 126147-98-6
(2S,3S)-2,3-Dihydroxy-succinic acid; compound with (R)-pyrrolidine-2-carboxylic acid
- 344-25-2
D-Prolin
| Conditions | Yield |
|---|---|
| With ammonium hydroxide 1.) methanol, 0.5 h; Yield given. Multistep reaction; |
- 96293-17-3, 105024-93-9, 105112-33-2
(S)-N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide
- 107-02-8
acrolein
A
- 147-85-3
L-proline
B
- 344-25-2
D-Prolin
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate; triethylamine; nickel(II) nitrate Yield given. Multistep reaction. Yields of byproduct given; |
- 344-25-2
D-Prolin
| Conditions | Yield |
|---|---|
| With hydrogenchloride; nitrosylchloride Erhitzen des Reaktionsprodukts mit wss. Ba(OH)2; |
- 344-25-2
D-Prolin
| Conditions | Yield |
|---|---|
| With Cinchonin |
Proline Chemical Properties
Molecular Structure of D-Proline (CAS NO.344-25-2):
.png)
IUPAC Name: (2R)-pyrrolidin-1-ium-2-carboxylate
Empirical Formula: C5H9NO2
Molecular Weight: 115.1305
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 29.54 Å2
Index of Refraction: 1.487
Molar Refractivity: 27.9 cm3
Molar Volume: 96.9 cm3
Surface Tension: 43.4 dyne/cm
Density: 1.186 g/cm3
Flash Point: 106.3 °C
Enthalpy of Vaporization: 53.9 kJ/mol
Boiling Point: 252.2 °C at 760 mmHg
Vapour Pressure: 0.00615 mmHg at 25°C
EINECS: 206-452-7
Melting point:223 °C (dec.)(lit.)
Alpha: 84.75 o (C=4, H2O)
Refractive index: 85 ° (C=4, H2O)
Storage temp: Store at RT
Water Solubility: soluble >1000 g/L (20 oC)
Melting point: 223 °C (dec.)(lit.)
Product Categories: Amino Acids series; Miscellaneous Biochemicals; Proline [Pro, P]; Amino Acids and Derivatives; alpha-Amino Acids; Amino Acids;Biochemistry; Amino Acids and Derivatives
Proline Uses
D-Proline (CAS NO.344-25-2) is used as synthesizing the drugs.
Proline Safety Profile
Hazard Codes of D-Proline (CAS NO.344-25-2): 
Xi,
Xn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36/37/39-26
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
F: 3-10
Hazard Note: Irritant
Proline Specification
D-Proline , with CAS number of 344-25-2, can be called (2R)-2-Pyrrolidinecarboxylic acid ; (R)-(+)-Proline ; (+)-(R)-Proline ; (R)-Proline ; (R)-Pyrrolidine-2-carboxylic acid ; D-(+)-Proline; D-Pyrrolidine-2-carboxylic acid ; (R)-pyrrolidine-2-carboxylic acid . It is a white to off-white powder.
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