NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 231.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human No Adequate Data IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 231.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Community Right-To-Know List. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

The Safrole, with the CAS registry number 94-59-7, is also known as 4-Allyl-1,2-methylenedioxybenzene. It belongs to the product category of Aromatic Ethers. Its EINECS number is 202-345-4. This chemical's molecular formula is C₁₀H₁₀O₂ and molecular weight is 162.19. What's more, its systematic name is 5-Allyl-1,3-benzodioxole. Its classification codes are: (1)Mutation data; (2)Natural Product; (3)Reproductive Effect; (4)Skin / Eye Irritant; (5)Tumor data. This chemical should be stored in a galvanized iron bucket or glass bottle which are placed in cool and dry places. Moreover, it should be protected from heat and fire. It is a colorless or slightly yellow oily liquid. It is typically extracted from the root-bark or the fruit of sassafras plants in the form of sassafras oil or synthesized from other related methylenedioxy compounds. It is the principal component of brown camphor oil, and is found in small amounts in a wide variety of plants, where it functions as a natural pesticide. 

Physical properties of Safrole are: (1)ACD/LogP: 3.098; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.10; (4)ACD/LogD (pH 7.4): 3.10; (5)ACD/BCF (pH 5.5): 133.13; (6)ACD/BCF (pH 7.4): 133.13; (7)ACD/KOC (pH 5.5): 1153.87; (8)ACD/KOC (pH 7.4): 1153.87; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 18.46 Å²; (13)Index of Refraction: 1.551; (14)Molar Refractivity: 46.322 cm³; (15)Molar Volume: 145.029 cm³; (16)Polarizability: 18.363×10^-24cm³; (17)Surface Tension: 41.5 dyne/cm; (18)Density: 1.118 g/cm³; (19)Flash Point: 97.778 °C; (20)Enthalpy of Vaporization: 45.072 kJ/mol; (21)Boiling Point: 233.087 °C at 760 mmHg; (22)Vapour Pressure: 0.09 mmHg at 25°C.

Preparation of Safrole: this chemical can be prepared by 1-benzo[1,3]dioxol-5-yl-but-3-yn-2-ol at the temperature of 110 °C. This reaction will need reagents tris(1-pyrazolyl)borate]Ru(PPh₃)(CH₃CN)₂·PF₆, LiOTf and solvent toluene with the reaction time of 5 hours. The yield is about 70%.

Uses of Safrole: it can be used to produce 5-oxiranylmethyl-benzo[1,3]dioxole at the ambient temperature. It will need reagent CH₃CO₃H and solvent CHCl₃ with the reaction time of 72 hours. The yield is about 80%.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed. It may cause cancer and has a possible risk of irreversible effects. It should be avoided exposure, and you need to obtain special instructions before use. In case of accident or if you feel unwell, you must seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: C=CCc1ccc2OCOc2c1
(2)Std. InChI: InChI=1S/C10H10O2/c1-2-3-8-4-5-9-10(6-8)12-7-11-9/h2,4-6H,1,3,7H2
(3)Std. InChIKey: ZMQAAUBTXCXRIC-UHFFFAOYSA-N

The toxicity data is as follows:  

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	2350mg/kg (2350mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.
mouse	LD50	subcutaneous	1020mg/kg (1020mg/kg)	BEHAVIORAL: EXCITEMENT	Sapporo Igaku Zasshi. Sapporo Medical Journal. Vol. 3, Pg. 73, 1952.
rabbit	LD50	skin	> 5gm/kg (5000mg/kg)		Food and Cosmetics Toxicology. Vol. 12, Pg. 983, 1974.
rabbit	LDLo	intravenous	200mg/kg (200mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 35, Pg. 342, 1895.
rabbit	LDLo	oral	1gm/kg (1000mg/kg)	BEHAVIORAL: ATAXIA PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 35, Pg. 342, 1895.
rabbit	LDLo	subcutaneous	1gm/kg (1000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 35, Pg. 342, 1895.
rat	LD50	oral	1950mg/kg (1950mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toxicology and Applied Pharmacology. Vol. 7, Pg. 18, 1965.