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Somatotropin

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Name

Somatotropin

EINECS 235-735-8
CAS No. 12629-01-5 Density
Solubility Melting Point
Formula C990H1529N263O299S7 Boiling Point
Molecular Weight 22124.12 Flash Point
Transport Information Appearance lyophilized powder
Safety Risk Codes
Molecular Structure Molecular Structure of 12629-01-5 (Somatotropin (human)(9CI)) Hazard Symbols ExplosiveB
Synonyms

Bio-Tropin;CB 311;Corpormon;Crescormon;Genotonorm;Genotropin;Growthhormone (human pituitary);Human growth hormone;Humatrope;Infitropin CR;LB03002;LY 137998;Norditropin;Norditropin SimpleXx;Nordotropin;Nutropin;Nutropin Depot;Omnitrope;SJ 0011;SR 29001;Saizen;Somatogen;Somatotropin(human);Somatropin;Valtropin;Zomacton;Zorbtive;Somatotropin;

 

Somatotropin Specification

The systematic name of Somatropin is Growth hormone (human). With the CAS registry number 12629-01-5, it is also named as Human Growth Hormone. The product's classification codes are Drug / Therapeutic Agent; Growth hormone; Hormone [growth], and the other registry numbers are 11145-52-1; 869741-23-1. Besides, it is lyophilized powder, which should be stored at 2-8 °C. In addition, its molecular formula is C990H1529N263O299S7 and molecular weight is 22124.12.It is a 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.

Uses of Somatropin:
it can be used as prescription drug in medicine to treat children's growth disorders and adult growth hormone deficiency. It is also used as an anabolic agent. Additionally, it can be used in raising livestock more efficiently in industrial agriculture.

The toxicity data of Somatotropin is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 intramuscular 16iu/kg (16iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.
monkey LD50 subcutaneous > 20iu/kg (20iu/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 5693, 1987.
mouse LD50 intramuscular 40iu/kg (40iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.
mouse LD50 oral 160iu/kg (160iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.
mouse LD50 subcutaneous 80iu/kg (80iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.
rat LD50 intramuscular 40iu/kg (40iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.
rat LD50 oral 160iu/kg (160iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.
rat LD50 subcutaneous 80iu/kg (80iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.

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