Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Sulfaquinoxaline

Related Products

Hot Products

Name

Sulfaquinoxaline

EINECS 200-423-2
CAS No. 59-40-5 Density 1.491 g/cm3
PSA 106.35000 LogP 3.74780
Solubility Insoluble in water, ethanol and acetone, soluble in alkaline solution Melting Point 247-248 °C
Formula C14H12N4O2S Boiling Point 551.1 °C at 760 mmHg
Molecular Weight 300.341 Flash Point 287.1 °C
Transport Information N/A Appearance light yellow crystalline powder
Safety 22-36/37-45 Risk Codes 22-42/43
Molecular Structure Molecular Structure of 59-40-5 (Sulfaquinoxaline) Hazard Symbols HarmfulXn
Synonyms

Sulfanilamide,N1-2-quinoxalinyl- (6CI,7CI,8CI);2-(p-Sulfanilamido)quinoxaline;2-Sulfanilamidobenzopyrazine;2-p-Aminobenzenesulfonamidoquinoxaline;2-p-Aminobenzenesulphonamidoquinoxaline;Avicocid;Compound 3-120;Italquina;Kokozigal;N1-(2-Quinoxalinyl)sulfanilamide;NSC 41805;SQ 40;SQX;Sulfa-Q 20;Sulfabenzpyrazine;Sulfaline;Sulfaquinoxaline;Sulphaquinoxaline;Sulquin;Ursokoxaline;

Article Data 7

Sulfaquinoxaline Synthetic route

63-74-1

sulfanilamide

79-11-8

chloroacetic acid

95-54-5

1,2-diamino-benzene

59-40-5

sulphaquinoxaline

Conditions
ConditionsYield
Stage #1: chloroacetic acid; 1,2-diamino-benzene With N'-methyl-N-heptylimidazolium hydroxide salt at 100℃; for 2h;
Stage #2: sulfanilamide With trichlorophosphate at 100℃; for 3h; Concentration; Temperature;
93%
6632-67-3

N-[4-(quinoxalin-2-ylsulfamoyl)phenyl]acetamide

59-40-5

sulphaquinoxaline

Conditions
ConditionsYield
With sodium hydroxide In water for 2h; Heating;91.2%
With hydrogenchloride; ethanol; water
1448-87-9

2-chloroquinoxaline

63-74-1

sulfanilamide

59-40-5

sulphaquinoxaline

5424-05-5

quinoxalin-2-ylamine

59-40-5

sulphaquinoxaline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 31.6 percent / pyridine / 25 °C
2: 91.2 percent / NaOH / H2O / 2 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: pyridine
2: water; ethanol; HCl
View Scheme
121-60-8

p-acetylaminobenzenesulfonyl chloride

4-acetoxy-N1-acetyl-o-phenylenediamine

4-acetoxy-N1-acetyl-o-phenylenediamine

59-40-5

sulphaquinoxaline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 31.6 percent / pyridine / 25 °C
2: 91.2 percent / NaOH / H2O / 2 h / Heating
View Scheme
85414-82-0

2-aminoquinoxaline-3-carboxylic acid

59-40-5

sulphaquinoxaline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: nitrobenzene
2: pyridine
3: water; ethanol; HCl
View Scheme
121-60-8

p-acetylaminobenzenesulfonyl chloride

59-40-5

sulphaquinoxaline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: water; ethanol; HCl
View Scheme
490-59-5

alloxazine

59-40-5

sulphaquinoxaline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; H2SO4
2: pyridine
3: water; ethanol; HCl
View Scheme
Multi-step reaction with 4 steps
1: water; NH3 / 175 °C
2: nitrobenzene
3: pyridine
4: water; ethanol; HCl
View Scheme
59-40-5

sulphaquinoxaline

439-14-5

diazepam

4-([4-{7-chloro-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl}phenyl]diazenyl)-N-(quinoxalin-2-yl)benzenesulfonamide

Conditions
ConditionsYield
Stage #1: sulphaquinoxaline With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.0833333h; Green chemistry;
Stage #2: diazepam With sodium acetate In ethanol; water Green chemistry;
90%
463-71-8

thiophosgene

59-40-5

sulphaquinoxaline

681235-15-4

4-isothiocyanato-N-(quinoxalin-2-yl)benzenesulfonamide

Conditions
ConditionsYield
In water for 1h;86%

Sulfaquinoxaline Consensus Reports

Reported in EPA TSCA Inventory.

Sulfaquinoxaline Specification

The IUPAC name of Sulfaquinoxaline is 4-amino-N-quinoxalin-2-ylbenzenesulfonamide. With the CAS registry number 59-40-5, it is also named as 2-(p-Sulfanilamido)quinoxaline. The product's categories are Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds. It is light yellow crystalline powder which is insoluble in water, ethanol and acetone, soluble in alkaline solution. When heated to decomposition it emits very toxic fumes of NOx and SOx. Additioanlly, this chemical should be sealed in the container.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.63; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.57; (4)ACD/LogD (pH 7.4): -0.48; (5)ACD/BCF (pH 5.5): 1.52; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 45.01; (8)ACD/KOC (pH 7.4): 4.07; (9)#H bond acceptors: 6; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.733; (13)Molar Refractivity: 80.7 cm3; (14)Molar Volume: 201.3 cm3; (15)Polarizability: 31.99×10-24 cm3; (16)Surface Tension: 83.7 dyne/cm; (17)Enthalpy of Vaporization: 83.13 kJ/mol; (18)Vapour Pressure: 3.42E-12 mmHg at 25°C; (19)Rotatable Bond Count: 3; (20)Tautomer Count: 2; (21)Exact Mass: 300.068096; (22)MonoIsotopic Mass: 300.068096; (23)Topological Polar Surface Area: 106; (24)Heavy Atom Count: 21; (25)Complexity: 442.

Preparation of Sulfaquinoxaline: Using o-phenylenediamine as raw material. Firstly, o-phenylenediamine reacts with sodium cyanide, formaldehyde in acidic media to obtain N-cyanomethyl-o-phenylenediamine. Secondly, the cyclization of N-cyanomethyl-o-phenylenediamine and potassium hydroxide to generate 2-amino-3,4-dihydro-yl. Thirdly, using hydrogen peroxide to dehydrogenize in the presence of ferrous chloride to get 2-amino-quinoxaline. Finally, after condensation and hydrolysis with acetylsulfanilyl chloride
sulfonamides, we can get the product.

Uses of Sulfaquinoxaline: It is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis. It is also used as an animal-specific broad-spectrum antimicrobial agent, which is more toxic to mammals.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. And it also may cause sensitization by inhalation and skin contact, so people should not breathe dust. If you want to contact this product, you must wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
1. SMILES:O=S(=O)(c1ccc(N)cc1)Nc2nc3ccccc3nc2
2. InChI:InChI=1/C14H12N4O2S/c15-10-5-7-11(8-6-10)21(19,20)18-14-9-16-12-3-1-2-4-13(12)17-14/h1-9H,15H2,(H,17,18) 
3. InChIKey:NHZLNPMOSADWGC-UHFFFAOYAA

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 15gm/kg (15000mg/kg)   "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A370, Pg. 1983,
rat LD50 oral 1370mg/kg (1370mg/kg)   Personal Communication from W.M. Mahlburg, Hopkins Agricultural Chemical Co., P.O. Box 7532, Madison, WI 53707, Nov. 16, 1982Vol. 16NOV1982,

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 59-40-5