- 1738-86-9Glycine,N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester
- 1738-87-0L-Leucine,N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester
- 173894-27-43-Butyl-2-[5-(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)-1,3-pentadien-1-yl]-1,1-dimethyl-1H-benz[e]indolium perchlorate
- 173897-44-4Y 39983, 2 HCl salt
- 173898-21-0Benzamide,4-(1-aminoethyl)-, (R)- (9CI)
- 1739-00-0Benzeneethanamine,N-phenyl-
- 173900-45-3Benzonitrile, 3-chloro-4-hydroxy-5-methyl-
- 173901-03-63-Pyridinemethanol, a-(chloromethyl)-, (aR)-
- 173901-15-0Benzonitrile, 3-oxiranyl-, (R)- (9CI)
- 173903-15-6Carbamic acid,N-(chlorocarbonyl)-N-[4-(trifluoromethoxy)phenyl]-, methyl ester
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
Swertiamarine |
EINECS | N/A |
| CAS No. | 17388-39-5 | Density | 1.57 g/cm3 |
| PSA | 155.14000 | LogP | -2.47670 |
| Solubility | N/A | Melting Point |
111oC |
| Formula | C16H22O10 | Boiling Point | 649.3 °C at 760 mmHg |
| Molecular Weight | 374.345 | Flash Point | 237.7 °C |
| Transport Information | N/A | Appearance | white powder |
| Safety | 24/25 | Risk Codes | R23; R34 |
| Molecular Structure |
|
Hazard Symbols |
 C
|
| Synonyms |
1H,3H-Pyrano[3,4-c]pyran-1-one,5-ethenyl-6-(b-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-,[4aR-(4aa,5b,6a)]-;Swertiamarin (6CI,7CI,8CI);Swertiamaroside;swertiamarin; |
Article Data | 1 |
Swertiamarine Chemical Properties
IUPAC Name: (4aR,5R,6S)-5-Ethenyl-4a-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4,5,6-tetrahydropyrano[3,4-c]pyran-1-one
Molecular Formula: C16H22O10
Molecular Weight: 374.34
Density: 1.57 g/cm3
Melting Point: 111°C
Flash Point: 237.7°C
Boiling Point: 649.3°C at 760 mmHg
LogP: ACD/LogP: -3.15
XLogP: -1.90
ACD/LogD (pH 5.5): -3.15
ACD/LogD (pH 7.4): -3.15
ACD/BCF (pH 5.5): 1
ACD/BCF (pH 7.4): 1
ACD/KOC (pH 5.5): 1
ACD/KOC (pH 7.4): 1
H bond acceptors: 10
H bond donors: 5
Freely Rotating Bonds: 9
Index of Refraction: 1.625
Molar Refractivity: 84.06 cm3
Molar Volume: 237.5 cm3
Surface Tension: 79.3 dyne/cm
Enthalpy of Vaporization: 109.62 kJ/mol
The molecular structure of Swertiamarin (CAS NO. 17388-39-5):
Swertiamarine Uses
Swertiamarin (CAS NO. 17388-39-5) is often blended in general gastroenteric drugs as a bitter stomachic.This product is on isolated rat duodenum, uterus, gallbladder and bile duct sphincter muscle of the autonomous rhythmic activity were inhibited, and can fight against acetylcholine, norepinephrine and other excitatory effect on these organs. Clinical application proved that the product of the gastrointestinal tract, biliary tract spasm of smooth muscle spasm pain has obvious analgesic effect, there is a certain sedative effect, and no allergic and irritant.
Swertiamarine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | > 8gm/kg (8000mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 13, Pg. 464, 1982. |
| mouse | LD50 | intravenous | > 5gm/kg (5000mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 13, Pg. 464, 1982. |
| mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 13, Pg. 464, 1982. |
Swertiamarine Specification
Swertiamarin with cas registry number of 17388-39-5 is also called for (4aR-(4a-alpha,5-beta,6-alpha))-Ranosyloxy)-4a-hydroxy ; 1H,3H-Pyrano(3,4-c)pyran-1-one,4,4a,5,6-tetrahydro-5-ethenyl-6-(beta-d-glucopy) ; 3H-Pyrano[3,4-c]pyran-1-one,4,4.alpha.,5,6-tetrahydro-5-ethenyl-6-(.beta.-D-glucopyranosyloxy) ; Swertiamarin(6CI,7CI,8CI) ; Swertiamaroside ; MLS002473253 ; MEGxp0_000871 ; ACon1_000546 ; CID442435 ; ZINC04098354 ; NCGC00168975-01 ; SMR001397340 ; TL8001379 . The appearance of Swertiamarin (CAS NO. 17388-39-5) is white powder which is soluble in methanol , ethanol , slightly soluble in water , not soluble in chloroform , petroleum ether .
Treatment of Swertiamarin in Wastewater, see as follows :
Total removal: 1.85 percent
Total biodegradation: 0.09 percent
Total sludge adsorption: 1.75 percent
Total to Air: 0.00 percent
(using 10000 hr Bio P,A,S)
What can I do for you?
Get Best Price
