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Teicoplanin A2

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Name

Teicoplanin A2

EINECS N/A
CAS No. 61036-64-4 Density N/A
PSA 671.64000 LogP 4.28220
Solubility Soluble in DMF, dimethylsulfoxide and aqueous solution with pH of 7.0, partly soluble in methanol or ethanol, insoluble in dilute inorganic acid and the polar organic solvents Melting Point 260 ºC
Formula C78H77Cl2N8O32R Boiling Point N/A
Molecular Weight 1709.39 Flash Point N/A
Transport Information N/A Appearance Amorphous powder
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 61036-64-4 (Teicoplanin A2) Hazard Symbols N/A
Synonyms

Teicoplanin A 2 (9CI);Teichomycin A2;

 

Teicoplanin A2 Specification

The Teicoplanin A2, with the CAS registry number 61036-64-4, is also known as Teichomycin A2. This chemical's molecular formula is C78H78Cl2N9O32R. Its classification codes are: (1)Drug / Therapeutic Agent; (2)Natural Product. It is evaluated in vitro against clinical isolates, and its activity is compared with that of other antibiotics. This compound is very active against all organisms tested; its activity is comparable to that of vancomycin, and it is superior to several other antibiotics when tested against gram-positive cocci. Because of its in vitro activity, it deserves clinical evaluation. It is well tolerated and less toxic, non-destructive on renal function and has good effect on a variety of infections caused by Gram-positive bacteria. It can be derived from glycopeptide antibiotics produced by Actinplans teichomycetics nov.sp.

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C90H99Cl2N9O34/c1-5-6-7-8-9-10-11-12-60(110)95-69-76(116)73(113)58(32-103)132-89(69)135-80-55-27-41-28-56(80)128-51-20-16-39(23-46(51)92)79(134-88-68(94-35(3)105)75(115)72(112)57(31-102)131-88)70-86(124)99-66(87(125)126-4)44-29-42(106)30-54(130-90-78(118)77(117)74(114)59(33-104)133-90)61(44)43-21-37(14-17-47(43)107)63(82(120)101-70)96-84(122)65(41)97-83(121)64-40-24-49(109)34(2)52(26-40)129-53-25-36(13-18-48(53)108)62(93)81(119)100-67(85(123)98-64)71(111)38-15-19-50(127-55)45(91)22-38/h9-10,13-30,57-59,62-79,88-90,102-104,106-109,111-118H,5-8,11-12,31-33,93H2,1-4H3,(H,94,105)(H,95,110)(H,96,122)(H,97,121)(H,98,123)(H,99,124)(H,100,119)(H,101,120)/b10-9+
(2)Smiles: CCCCC\C=C\CCC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1Oc1c2Oc3ccc(cc3Cl)[C@@H](O[C@@H]3O[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]3NC(C)=O)[C@@H]3NC(=O)[C@@H](NC(=O)[C@@H]4NC(=O)[C@@H]5NC(=O)[C@@H](NC(=O)[C@@H](N)c6cc(c(O)cc6)Oc6c(C)c(cc5c6)O)[C@@H](O)c5ccc(Oc1cc4c2)c(c5)Cl)c1ccc(O)c(c1)c1c(O[C@@H]2O[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]2O)cc(O)cc1[C@@H](NC3=O)C(=O)OC

The toxicity data is as follows: 

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 1gm/kg (1000mg/kg)   Journal of Antibiotics. Vol. 31, Pg. 276, 1978.
mouse LD50 intravenous 275mg/kg (275mg/kg)   Journal of Antibiotics. Vol. 31, Pg. 276, 1978.
mouse LD50 oral > 1gm/kg (1000mg/kg)   Journal of Antibiotics. Vol. 31, Pg. 276, 1978.
mouse LD50 subcutaneous 2860mg/kg (2860mg/kg)   "Current Chemotherapy and Immunotherapy, Proceedings of the International Congress of Chemotherapy, 12th, 1981," Periti, P., and G. Gialdroni-Grassi, eds., 2 vols., Washington, DC American Soc. for Microbiology, 1982Vol. 12, Pg. 342, 1982.

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