- Terazosin
- Terazosin hydrochloride
- Terazosin hydrochloride dihydrate
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Cas Database |
| Name |
Terazosin |
EINECS | N/A |
| CAS No. | 63590-64-7 | Density | 1.332 g/cm3 |
| PSA | 103.04000 | LogP | 1.64090 |
| Solubility | 25 mg/mL in water | Melting Point |
281-283 °C |
| Formula | C19H25N5O4 | Boiling Point | 664.5 °C at 760 mmHg |
| Molecular Weight | 387.439 | Flash Point | 355.7 °C |
| Transport Information | N/A | Appearance | white to off-white crystalline powder |
| Safety | 26-36 | Risk Codes | 22-36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xn, Xi
|
| Synonyms |
Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-(9CI);1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine;1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-[(2,3,4,5-tetrahydrofuran-2-yl)carbonyl]piperazine;Terazosin;Fosfomic;Vasomet;Terazosina;Terazosine;Flumarc;Blavin; |
Article Data | 12 |
Terazosin Synthetic route
- 16874-33-2
tetrahydro-2-furancarboxylic acid
- 60547-97-9
4-amino-6,7-dimethoxy-2-piperazin-1-ylquinazoline
- 63590-64-7
terazosin
| Conditions | Yield |
|---|---|
| With N-ethyl-N,N-diisopropylamine; ethyl cyanoglyoxylate-2-oxime In N,N-dimethyl-formamide at 20℃; | 65% |
- 19237-84-4
prazosin hydrochloride
- 63590-64-7
terazosin
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In ethanol; water at 20℃; |
- 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine
- 63074-07-7
N-(tetrahydro-2-furoyl)-piperazine
- 63590-64-7
terazosin
- 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine
- 63074-07-7
N-(tetrahydro-2-furoyl)-piperazine
- 63590-64-7
terazosin
| Conditions | Yield |
|---|---|
| In water | 84 grams (87%) |
| In water | 90.8 grams (94%) |
| With triethylamine In water |
- 943644-21-1
1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4-[[(2RS)2,3,4,5-tetrahydrofuran-2-yl]carbonyl]piperazine hydrochloride hydrobromide
- 63590-64-7
terazosin
| Conditions | Yield |
|---|---|
| With ammonia In water at 25 - 45℃; for 1h; pH=8.4; |
- 63590-64-7
terazosin
| Conditions | Yield |
|---|---|
| With hydrogenchloride for 2.86667h; | |
| With hydrogenchloride In ethanol; water at 60 - 65℃; for 0.25h; |
Terazosin Specification
The IUPAC name of Terazosin is [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone. With the CAS registry number 63590-64-7, it is also named as Fosfomic. The product's categories are Terazosin; Intermediates & Fine Chemicals; Pharmaceuticals; API's; API. Besides, it is white to off-white crystalline powder. In addition, its molecular formula is C19H25N5O4 and molecular weight is 387.44.
The other characteristics of this product can be summarized as: (1)ACD/LogP: -0.96; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.95; (4)ACD/LogD (pH 7.4): -1.01; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 6.42; (9)#H bond acceptors: 9; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4 ; (12)Index of Refraction: 1.636; (13)Molar Refractivity: 104.26 cm3; (14)Molar Volume: 290.6 cm3; (15)Surface Tension: 64.1 dyne/cm; (16)Density: 1.332 g/cm3; (17)Flash Point: 355.7 °C; (18)Melting Point: 281-283 °C; (19)Solubility: H2O: 25 mg/mL; (20)Enthalpy of Vaporization: 97.72 kJ/mol; (21)Boiling Point: 664.5 °C at 760 mmHg; (22)Vapour Pressure: 1.59E-17 mmHg at 25 °C.
Preparation of Terazosin: this chemical can be prepared by Furoic acid. The reaction equation is as follows:
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Uses of Terazosin: this chemical is used for treatment of symptoms of an enlarged prostate (BPH) as selective alpha 1 antagonist. It is also used to lower the blood pressure. Additionally, it is used in the treatment of benign prostatic hyperplasia by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.
When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. It is also harmful if swallowed. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing.
People can use the following data to convert to the molecule structure.
(1)SMILES: O=C(N3CCN(c2nc1cc(OC)c(OC)cc1c(n2)N)CC3)C4OCCC4
(2)InChI: InChI=1/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22)
(3)InChIKey: VCKUSRYTPJJLNI-UHFFFAOYAV
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LDLo | oral | 3gm/kg (3000mg/kg) | United States Patent Document. Vol. #4734418, |
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