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Name	Tetrabutylphosphonium chloride	EINECS	218-964-8
CAS No.	2304-30-5	Density	0.978[at 20℃]
PSA	13.59000	LogP	3.20840
Solubility	N/A	Melting Point	62-66 °C
Formula	C₁₆H₃₆ClP	Boiling Point	344.8℃[at 101 325 Pa]
Molecular Weight	294.889	Flash Point	4°C (39°F)
Transport Information	UN 2928	Appearance	clear to yellowish liquid
Safety	26-36/37/39-45	Risk Codes	22-24-34
Molecular Structure		Hazard Symbols	T
Synonyms	Phosphonium,tetrabutyl-, chloride (8CI,9CI);Tetrabutylphosphonium chloride (7CI);Cyphos443P;Cyphos 443T;Cyphos IL 164;Hishicolin PX 4C;Tetra-n-butylphosphoniumchloride;	Article Data	10

Tetrabutylphosphonium chloride Synthetic route

: 109-69-3
n-Butyl chloride

: 998-40-3
tributylphosphine

: 2304-30-5
tetra-n-butylphosphonium chloride

Conditions

Conditions	Yield
In diethyl ether Reflux;	89%
at 115℃; for 72h;
at 50 - 95℃; for 192h; Inert atmosphere;
at 105℃; for 72h;

: 693-04-9
butyl magnesium bromide

: tri-n-butylchlorophosphonium chloride

: 2304-30-5
tetra-n-butylphosphonium chloride

Conditions

Conditions	Yield
Stage #1: butyl magnesium bromide; tri-n-butylchlorophosphonium chloride In tetrahydrofuran; dichloromethane at 0℃; for 0.75h; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether; water for 0.166667h;	80%

: 14518-69-5
tetra-n-butylphosphonium hydroxide

: 2304-30-5
tetra-n-butylphosphonium chloride

Conditions

Conditions	Yield
With hydrogenchloride In water
With hydrogenchloride In water
With hydrogenchloride In water

: 814-29-9
Tributylphosphine oxide

: 2304-30-5
tetra-n-butylphosphonium chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: oxalyl dichloride / 1 h / 20 °C / Inert atmosphere 2.1: dichloromethane; tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere 2.2: 0.17 h View Scheme

: 109-69-3
n-Butyl chloride

A: 106-98-9
1-butylene

B: 2304-30-5
tetra-n-butylphosphonium chloride

Conditions

Conditions	Yield
With tributylphosphine In (2)H8-toluene at 220℃; for 16h; Schlenk technique; Inert atmosphere; Sealed tube;

: C42H42N28O14*C16H36P(1+)*Cl(1-)

A: 2304-30-5
tetra-n-butylphosphonium chloride

B: 259886-50-5
cucurbituril

Conditions

Conditions	Yield
In methanol; water Equilibrium constant;

: 2304-30-5
tetra-n-butylphosphonium chloride

: tetrabutylphosphonium fluoride dihydrofluoride

Conditions

Conditions	Yield
With potassium hydrogen bifluoride In dichloromethane for 0.5h; Ambient temperature;	100%

: tris(pentafluoroethyl)trifluorophosphoric acid

: 2304-30-5
tetra-n-butylphosphonium chloride

: tetra(n-butyl)phosphonium tris(pentafluoroethyl)trifluorophosphate

Conditions

Conditions	Yield
In diethyl ether; toluene at 20℃; for 0.5h;	100%

: 63995-75-5
sodium 3-(diphenylphosphanyl)benzenesulfonate

: 2304-30-5
tetra-n-butylphosphonium chloride

: 1384498-21-8
tetrabutylphosphonium diphenyl(3-sulfonatophenyl)phosphine

Conditions

Conditions	Yield
In dichloromethane; water	99%

: 298-07-7
Bis(2-ethylhexyl)phosphoric acid

: 2304-30-5
tetra-n-butylphosphonium chloride

: tetrabutylphosphonium bis(2-ethylhexyl) phosphate

Conditions

Conditions	Yield
With sodium hydroxide In water; toluene at 70℃;	98%

Tetrabutylphosphonium chloride Specification

The IUPAC name of Tetra-N-butylphosphonium chloride is tetrabutylphosphanium chloride. With the CAS registry number 2304-30-5, it is also named as Phosphonium, tetrabutyl-, chloride. The product's product categories are Phosphonium Salts; Phosphonium Compounds; Greener Alternatives: Catalysis; Phase Transfer Catalysts; Phosphonium Salts. Besides, it is clear to yellowish liquid.

The other characteristics of this product can be summarized as: (1)H-Bond Donor: 0; (2)H-Bond Acceptor: 1; (3)Rotatable Bond Count: 12; (4)Exact Mass: 294.224315; (5)MonoIsotopic Mass: 294.224315; (6)Topological Polar Surface Area: 0; (7)Heavy Atom Count: 18; (8)Complexity: 116; (9)Melting Point: 62-66 °C; (10)EINECS: 218-964-8.

Uses of Tetra-N-butylphosphonium chloride: it can be used for producing C₁₆H₃₆P(1+)*2FH*F(1-).

This reaction needs aq. KHF₂ and CH₂Cl₂ at ambient temperature for 30 min. The yield is 100 %.

When you are using this chemical, please be cautious about it as the following: it is harmful if swallowed and toxic in contact with skin. It also may cause burns. Please wear suitable protective clothing, gloves and eye/face protection when use it. Moreover, in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
(1)SMILES:[Cl-].CCCC[P+](CCCC)(CCCC)CCCC
(2)InChI:InChI=1/C16H36P.ClH/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H/q+1;/p-1
(3)InChIKey:IBWGNZVCJVLSHB-REWHXWOFAC
(4)Std. InChI:InChI=1S/C16H36P.ClH/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H/q+1;/p-1
(5)Std. InChIKey:IBWGNZVCJVLSHB-UHFFFAOYSA-M

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intravenous	32mg/kg (32mg/kg)	U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03140,
rabbit	LD50	oral	325mg/kg (325mg/kg)	Toxicology. Vol. 24, Pg. 245, 1982.
rabbit	LD50	skin	121mg/kg (121mg/kg)	Office of Toxic Substances Report. Vol. FYI-OTS-1178-0020,
rat	LC50	inhalation	> 3mg/m³/1H (3mg/m³)	Toxicology. Vol. 24, Pg. 245, 1982.
rat	LD50	oral	916mg/kg (916mg/kg)	Toxicology. Vol. 24, Pg. 245, 1982.