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Cas Database

Name	Thymidine	EINECS	200-070-4
CAS No.	50-89-5	Density	1.452 g/cm³
PSA	104.55000	LogP	-1.51430
Solubility	soluble in water	Melting Point	186-188 °C(lit.)
Formula	C₁₀H₁₄N₂O₅	Boiling Point	385.05°C (rough estimate)
Molecular Weight	242.232	Flash Point	N/A
Transport Information	N/A	Appearance	white crystalline powder
Safety	22-24/25-37/39-26	Risk Codes	20/21/22-40-36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione;5-Methyl-2'-deoxyuridine;2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methyl-;2'-Deoxythymidine;5-Methyldeoxyurindine;Uridine, 2'-deoxy-5-methyl-beta-D-Ribofuranoside, thymine-1 2-deoxy-;dT;UNII-VC2W18DGKR;Thyminedeoxyriboside;Thymine-2-deoxyriboside;	Article Data	200

Thymidine Synthetic route

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 50-89-5
thymidine

Conditions

Conditions	Yield
With zinc dibromide In nitromethane for 0.0166667h; Ambient temperature;	100%
With zinc dibromide In nitromethane Kinetics; Ambient temperature; in various solvent:CH2Cl2, THF, Acetone, Dioxane; other 5'-deoxytritylnucleosides;	100%
With β-naphthol In dichloromethane for 0.166667h; Product distribution / selectivity; Irradiation with mercury arc lamp;	97%

: 7791-71-1
5'-O-tritylthymidine

: 50-89-5
thymidine

Conditions

Conditions	Yield
With silica gel; trifluoroacetic acid In methanol; chloroform	100%
Stage #1: 5'-O-tritylthymidine With carbon tetrabromide In methanol for 0.5h; Irradiation; Stage #2: In methanol at 20℃; for 12.5h;	97%
With carbon tetrabromide In methanol at 20℃; for 13h; Irradiation;	97%

: 1335224-06-0
1-[(2R,4S,5R)-5-(hydroxymethyl)-4-[2-(4-hydroxyphenyl)-2-oxoethoxy]tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4-dione

: 50-89-5
thymidine

Conditions

Conditions	Yield
In methanol; water for 0.00416667h; Photolysis;	100%

: 6979-97-1, 97834-40-7, 142405-86-5
3',5'-diacetylthymidine

: 50-89-5
thymidine

Conditions

Conditions	Yield
With lipase A from Aspergillus niger In aq. phosphate buffer; acetonitrile at 25℃; for 2h; pH=7; Enzymatic reaction;	99%
With ammonium hydroxide at 20℃; Inert atmosphere;
With methanol; sodium methylate at 44℃; under 760.051 Torr; for 1h; Large scale reaction;	295.6 g
With methanol; sodium methylate for 1h; Reflux;

: 40733-26-4
3',5'-O-di(tert-butyldimethylsilyl)thymidine

: 50-89-5
thymidine

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide for 1h; Ambient temperature;	98%
With tetrabutyl ammonium fluoride In tetrahydrofuran Ambient temperature;	95%
With acetyl chloride In methanol for 2.5h;	90%

: 167872-02-8
thymidine 5'-(3'',5''-dimethoxybenzoin)carbonate

: 50-89-5
thymidine

Conditions

Conditions	Yield
In benzene for 1h; Irradiation;	98%

: 82161-35-1
5'-O-(9-phenylthioxanthyl)-2'-deoxythimidine

: 50-89-5
thymidine

Conditions

Conditions	Yield
In water; acetonitrile Hydrolysis; Irradiation;	97%

: 6979-97-1, 97834-40-7, 142405-86-5
3',5'-diacetylthymidine

p2(Ac-Cys-(Asp)4-Asp-COOH)-modified immobilized BTL*S196C enzyme: p2(Ac-Cys-(Asp)4-Asp-COOH)-modified immobilized BTL*S196C enzyme

A: 35898-31-8
5'-O-acetylthymidine

B: 50-89-5
thymidine

Conditions

Conditions	Yield
With sodium acetate In acetonitrile at 25℃; for 100h; pH=5; pH-value; Time; Reagent/catalyst; regioselective reaction;	A 97% B 3%

: 40733-28-6
5'-tert-butyldimethylsilyloxy-2'-deoxythymidine

: 50-89-5
thymidine

Conditions

Conditions	Yield
With Decaborane In tetrahydrofuran; methanol at 20℃; for 6h;	96%
With iodine(I) bromide In methanol; dichloromethane for 2h; Ambient temperature;	95%
With potassium tert-butylate In N,N-dimethyl-formamide for 24h; Ambient temperature;	92%

: C23H31BN2O7

: 50-89-5
thymidine

Conditions

Conditions	Yield
With dihydrogen peroxide In aq. phosphate buffer; dimethyl sulfoxide at 20℃; for 0.333333h; pH=7.2; Reagent/catalyst;	96%

Thymidine Chemical Properties

Molecular structure of Thymidine (CAS NO.50-89-5) is:

Product Name: Thymidine
CAS Registry Number: 50-89-5
IUPAC Name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Molecular Weight: 242.22856 [g/mol]
Molecular Formula: C₁₀H₁₄N₂O₅
XLogP3: -1.2
H-Bond Donor: 3
H-Bond Acceptor: 5
Melting Point: 186-188 °C(lit.)
Refractive index: 33 ° (C=1, 1mol/L NaOH)
Storage temp.: 0-6°C
Water Solubility: Soluble
Stability: Stable. Incompatible with strong oxidizing agents.
Surface Tension: 62.2 dyne/cm
Density: 1.452 g/cm³Product Categories: Fine Chemical & Intermediates; Pyridines, Pyrimidines, Purines and Pteredines; chiral; API intermediates; Zidovudine; Stavudine; Biochemistry; Nucleosides and their analogs; Nucleosides, Nucleotides & Related Reagents; Anti-virals; Bases & Related Reagents; Carbohydrates & Derivatives; Intermediates & Fine Chemicals; Nucleotides; Pharmaceuticals; Miscellaneous Specialties

Thymidine Uses

In cell biology, Thymidine (CAS NO.50-89-5) is used to synchronize the cells in S phase. It is commonly used in cell proliferation assays. It is used as pharmaceutical intermediates, it is used for synthesis of antiviral and anti-HIV drugs.

Thymidine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	2512mg/kg (2512mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Journal of Pharmacology and Experimental Therapeutics. Vol. 207, Pg. 504, 1978.

Thymidine Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Thymidine Safety Profile

Safty information about Thymidine (CAS NO.50-89-5) is:
Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes: Irritant Xi
Risk Statements: 20/21/22-40-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
R40: Limited evidence of a carcinogenic effect
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements 22-24/25-37/39-26
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S37/39: Wear suitable gloves and eye/face protection
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
F 10: Keep under argon.
WGK Germany: 3
RTECS: XP2071000

Thymidine Specification

Thymidine , its cas register number is 50-89-5. It also can be called 1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione ; 2'-Deoxythymidine ; 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methyl- ; 5-Methyl-2'-deoxyuridine ; 5-Methyldeoxyuridine ; 5-Methyldeoxyurindine ; AI3-52267 ; CCRIS 1283 ; DThyd ; Deoxythymidine ; NSC 21548 ; Thymidin ; Thymidine ; Thymine-2-deoxyriboside ; Thymine-2-desoxyriboside ; Thyminedeoxyriboside ; UNII-VC2W18DGKR ; Uridine, 2'-deoxy-5-methyl-beta-D-Ribofuranoside, thymine-1 2-deoxy- ; dT . It is a white crystalline powder.

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