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Chemical Baike

5-Exo-Dig Cyclization

After the formation of the α-oxo phosphonate intermediate, it can undergo a 5-exo-dig cyclization. This means that an intramolecular nucleophilic attack occurs on the electrophilic center created by the α-oxo group. This can lead to the formation of a cyclic compound, specifically a 1H-pyrrol-2-ylphosphonate if the reaction is designed for this outcome.

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