This reaction typically begins with the Kabachnik-Fields reaction, which is a reaction between an acetylenic aldehyde and a phosphite source (usually dialkyl phosphite). The reaction can be catalyzed by various Lewis acids or metal catalysts. The mechanism involves the formation of an α-oxo phosphonate intermediate. The acetylenic aldehyde reacts with the phosphite to form the corresponding α-oxo phosphonate.
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1-benzyl-2-cyclopropylethynyl-1H-indole-3-carbaldehyde
Phosphonic acid, [(2-chlorophenyl)(phenylamino)methyl]-, diethyl ester
