Biochemical assay

Test to measure the inhibitory effect of LM98 on TEAD protein

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Organic compounds Inhibitors Molecular docking Molecular modeling Pharmacophore binding affinity Minimum inhibitory concentration (MIC) Hydrogen bonding Sulfonamide X-ray crystallography Enzyme inhibition Inhibitor Histamine Cell Culture Lead Optimization Trypanosoma cruzi Structure-Activity Relationship (SAR) Enzyme Kinetics Drug Development Selective Inhibition Substrate Specificity High-Throughput Screening (HTS) Biological Activity Oxidative Decarboxylation Dose-Response Curve Catalytic Activity tRNA (Transfer RNA) Experimental Design Kinetic Analysis Catalytic Mechanism In vitro assay Chagas disease Small-molecule Bacterial cell wall synthesis Active site Cell viability assay Inflammatory mediators Cofactor Antibiotic resistance Sulfoxide group Peptidoglycan Gram-positive bacteria Allosteric site Catalytic site IC50 (Half-Maximal Inhibitory Concentration) Ki (Inhibition constant) Hydrophobic tail Enzyme-substrate complex Histone Deacetylase (HDAC)

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