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Chemical Baike

DNA Binding Affinity

To assess the DNA binding affinity of these metal-quinone complexes, you can use various spectroscopic techniques like UV-Vis, fluorescence spectroscopy, or circular dichroism (CD). These methods can help you determine the binding constant (Kb) and binding mode (intercalation, groove binding, or electrostatic interactions) of the complexes with DNA. A decrease in the absorption or fluorescence intensity of the metal-quinone complex upon DNA binding can indicate the formation of a complex.

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