The key step in the synthesis is the enantioselective addition of a nucleophile, such as an amine or an alcohol, to a suitable electrophilic substrate. The chiral Ti(IV) Schiff base catalyst facilitates this addition with high enantioselectivity.
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(-)-Benzal-α-phenyl-ethylamin
(1S,2R)-2-((5-methylthiophen-2-yl)methyleneamino)-1-phenylpropan-1-ol
1-(R)-(+)-tert-butylsulfinyl-2-methoxybenzene
(S,S)-2,4-bis<(tert-butyldimethylsiloxy)methyl>-N-<(S)-1-phenylethyl>azetidine
