The synthesized penam sulfones are then evaluated for their ability to inhibit β-lactamases. This is typically done through in vitro assays using purified β-lactamase enzymes.
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benzhydryl 2β-(chloroacetoxy)methyl-1,1-dioxo-penicillanate
(1S,2S,3S,4S,5S,6R,7R,8R)-6,7-bis(tert-butyldimethylsilyloxy)-8-(4-methoxybenzyloxy)cyclooctane-1,2,3,4,5-pentaol
7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin
