Mechanism-based isocoumarin inhibitors for blood coagulation serine proteases. Effect of the 7-substituent in 7-amino-4-chloro-3- (isothioureidoalkoxy)isocoumarins on inhibitory and anticoagulant potency

DOI: 10.1021/jm00035a009

Source and publish data:

Journal of Medicinal Chemistry p. 1298 - 1306 (1994)

Update date:2022-07-29

Topics: Enzyme Inhibition Assays Inhibitory Potency Mechanism-based Structure-activity relationship studies

Authors:

Kam Kam

Kerrigan

Plaskon Plaskon

Duffy Duffy

Lollar Lollar

Suddath Suddath

Powers Powers

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Article abstract of DOI:10.1021/jm00035a009

A series of 7-amino-4-chloro-3-(3-isothioureidopropoxy)isocoumarin (NH₂- CiTPrOIC) derivatives with various substituents at the 7- and 3-positions have been synthesized as inhibitors of several blood coagulation enzymes. Isocoumarins substitute

Full text of DOI:10.1021/jm00035a009

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