Journal of Medicinal Chemistry p. 1298 - 1306 (1994)
Update date:2022-07-29
Topics: Enzyme Inhibition Assays Inhibitory Potency Mechanism-based Structure-activity relationship studies
Kam
Kerrigan
Plaskon
Duffy
Lollar
Suddath
Powers
A series of 7-amino-4-chloro-3-(3-isothioureidopropoxy)isocoumarin (NH2- CiTPrOIC) derivatives with various substituents at the 7- and 3-positions have been synthesized as inhibitors of several blood coagulation enzymes. Isocoumarins substitute
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