Mechanism-based isocoumarin inhibitors for blood coagulation serine proteases. Effect of the 7-substituent in 7-amino-4-chloro-3- (isothioureidoalkoxy)isocoumarins on inhibitory and anticoagulant potency

Article abstract of DOI:10.1021/jm00035a009

A series of 7-amino-4-chloro-3-(3-isothioureidopropoxy)isocoumarin (NH₂- CiTPrOIC) derivatives with various substituents at the 7- and 3-positions have been synthesized as inhibitors of several blood coagulation enzymes. Isocoumarins substitute