Tetrahedron Letters p. 694 - 698 (2017)
Update date:2022-08-04
Topics: Efficient Eco-Friendly Kabachnik-Fields Reaction α-amino phosphonates Protocol
Khatri, Chetan K.
Satalkar, Vardhan B.
Chaturbhuj, Ganesh U.
An efficient, and environmentally benign protocol for a three-component Kabachnik-Fields reaction of aldehydes, amines, and diethyl phosphite catalyzed by sulfated polyborate has been described to afford α-amino phosphonates under solvent-free reaction conditions. The major advantages of the present method are high yields, short reaction time, simple work-up procedure, inexpensive, eco-friendly and reusable catalyst and solvent-free reaction conditions and tolerance towards various functional groups present in the substrates.
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