Balance lipophilicity to improve oral bioavailability. Too much lipophilicity may lead to poor solubility, while too little can lead to poor absorption. Incorporate polar functional groups or solubilizing moieties to improve solubility.
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5-CARBOXYBENZIMIDAZOLONE METHYL ESTER
tert-Butyl 3-{4-[4-(4-amidinophenyl)-1-piperazinyl]phenyl}propionate
Chlorobenzene
