To improve oral bioavailability and reduce potential toxicity, consider replacing or modifying parts of the phenylpiperazine scaffold with bioisosteric groups that maintain the key interactions with the GPIIb/IIIa receptor.
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tert-Butyl 3-{4-[4-(4-amidinophenyl)-1-piperazinyl]phenyl}propionate
Chlorobenzene
5-Morpholinothiophene-2-carboxylic acid
acetic acid 3-phenyl-pyridin-2-ylmethyl ester
4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-(benzyloxy)-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-<(tetrahydropyran-2-yl)oxy>-3,4,5,6-tetrahydro-2H-pyran
Benzene, 1,2,3-trimethoxy-5-[(1E)-2-(4-methoxy-3-nitrophenyl)ethenyl]-
