Spiro compounds can often be synthesized through the Michael addition reaction. A Michael acceptor is a compound containing a double bond and an electron-withdrawing group, while the Michael donor is typically a nucleophile. Asymmetric Michael additions can be used to construct the spiro ring systems. Chiral catalysts or auxiliaries can be used in such reactions to control chirality.
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(3R,7aS)-3-phenyl-7a-(3-phenylpropyl)-2,3,7,7a-tetrahydropyrrolo[2,1-b]oxazol-5-one
9-[(2R,3S,4R,5R)-3-Benzylamino-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-4-(toluene-4-sulfonyl)-tetrahydro-furan-2-yl]-9H-purin-6-ylamine
