Introduce a suitable photoaffinity group. Common photoaffinity groups include aryl azides (e.g., phenyl azide), diazirines, and benzophenone. You can attach this group to adenophostin A using standard chemical reactions. For example, you can react adenophostin A with a photoaffinity reagent containing the desired group. The specific reaction conditions will depend on the chosen photoaffinity reagent.
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4-(benzoyl)benzenepropanoic acid N-hydroxysuccinimide ester
(1R,2R,5S)-7-Methylene-2-((S)-1-phenyl-ethyl)-bicyclo[3.3.1]nonan-3-one
N-HEXADECYLMETHACRYLAMIDE
Benzoic acid, 4-(4-ethoxy-4-oxobutoxy)-
C25H32N4O3
C17H27NO3
3-Oxazolidinecarbothioamide, 2-[2-[2-[4-(3-fluorophenyl)-1-piperazinyl]ethoxy]phenyl]-N-methyl-
N-methyl-2-{2-[2-(4-(3-fluorophenyl)-1,2,3,6-tetrahydropyridin-1-yl)ethyloxy]phenyl}thiazolidine-3-carbothioamide
N-(Benzoyl)-(R)-3-methyl-N'-[(4-fluoro-indol-3-yl)-oxoacetyl]-piperazine
2-(3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole
3-amino-2-<2-(3,4-dimethoxyphenyl)ethyl>quinazolin-4(3H)-one
N-{1-benzyl-2,4,6-trioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-(2-oxopyrrolidin-1-yl)acetamide
Albutoin
5-(1H-benzimidazol-2-yl)-3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine
diethyl 1-cyclohexylaziridin-2-ylphosphonate
Methanone, (4-bromophenyl)(4-phenoxyphenyl)-
