Select a suitable nucleoside precursor with the desired chirality (S-configuration). Introduce the nucleoside moiety to the methanocarbaribo uracil core through a glycosidic bond-forming reaction.
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ethyl (2R,5R)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]-8,8-dimethyl-7,9-dioxatricyclo[4.3.0.02,4]nonane-2-carboxylate
